EFFECT OF EXOGENOUS TESTOSTERONE, FINASTERIDE, AND CASTRATION ON SERUM LEVEL OF THYROXINE

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ZAREI FATEMEH; YOUSOFVAND NAMDAR; KHAZAEI MOZAFAR; GHANBARI ALI

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2013 | Volume:17 | Issue:4 Page(s): 221-224

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Title

EFFECT OF EXOGENOUS TESTOSTERONE, FINASTERIDE, AND CASTRATION ON SERUM LEVEL OF THYROXINE

Author(s)

ZAREI FATEMEH | YOUSOFVAND NAMDAR | KHAZAEI MOZAFAR | GHANBARI ALI | Issue Writer Certificate

Keywords

FINASTERIDE

RATS

TESTOSTERONE

THYROXINE

Abstract

Background: The secretion of THYROXINE (T4) as the main hormone of thyroid gland is regulated by androgens. The present study aimed to evaluate the effect of TESTOSTERONE and FINASTERIDE administration and castration on serum levels of T4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate.Methods: Male adult RATS (n=32) were divided into 4 groups (n=8): Group 1 (control), Group 2 (castration), Group 3 (FINASTERIDE: 20 mg/kg/day) and Group 4 (testosterone: 5 mg/kg/day). At the end of the study (35 days), serum level of THYROXINE, body weight, weight of testis, and prostate were determined.Results: The data showed that the body weight increased in castrated (P=0.04) and decreased in TESTOSTERONE (P=0.00) groups but did not differ in FINASTERIDE (P>0.05) group. There were not any differences in the weight of testis among control, FINASTERIDE, and TESTOSTERONE groups but the weight of prostate increased in TESTOSTERONE group (P=0.00) and decreased in castrated (P=0.03) and FINASTERIDE groups (P=0.04). In addition, the serum level of T4 (nmo/ml) decreased in the three groups: FINASTERIDE (P=0.03), TESTOSTERONE (P=0.04), and castrated (P=0.00).Conclusion: TESTOSTERONE in both high and low levels decreased the amount of T4 with a time-dependent manner.

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APA: Copy

ZAREI, FATEMEH, YOUSOFVAND, NAMDAR, KHAZAEI, MOZAFAR, & GHANBARI, ALI. (2013). EFFECT OF EXOGENOUS TESTOSTERONE, FINASTERIDE, AND CASTRATION ON SERUM LEVEL OF THYROXINE. IRANIAN BIOMEDICAL JOURNAL, 17(4), 221-224. SID. https://sid.ir/paper/277357/en

Vancouver: Copy

ZAREI FATEMEH, YOUSOFVAND NAMDAR, KHAZAEI MOZAFAR, GHANBARI ALI. EFFECT OF EXOGENOUS TESTOSTERONE, FINASTERIDE, AND CASTRATION ON SERUM LEVEL OF THYROXINE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2013;17(4):221-224. Available from: https://sid.ir/paper/277357/en

IEEE: Copy

FATEMEH ZAREI, NAMDAR YOUSOFVAND, MOZAFAR KHAZAEI, and ALI GHANBARI, “EFFECT OF EXOGENOUS TESTOSTERONE, FINASTERIDE, AND CASTRATION ON SERUM LEVEL OF THYROXINE,” IRANIAN BIOMEDICAL JOURNAL, vol. 17, no. 4, pp. 221–224, 2013, [Online]. Available: https://sid.ir/paper/277357/en

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