MICROGLIAL ACTIVATION IN RAT EXPERIMENTAL SPINAL CORD INJURY MODEL

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ABDANIPOUR ALIREZA; TIRAIHI TAKI; TAHERI TAHER; KAZEMI HADI

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Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2013 | Volume:17 | Issue:4 Page(s): 214-220

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Information Journal Paper

Title

MICROGLIAL ACTIVATION IN RAT EXPERIMENTAL SPINAL CORD INJURY MODEL

Author(s)

ABDANIPOUR ALIREZA | TIRAIHI TAKI | TAHERI TAHER | KAZEMI HADI | Issue Writer Certificate

Keywords

SPINAL CORD INJURIES

INFLAMMATION

MICROGLIA

MACROPHAGES

Abstract

Background: The present study was designed to evaluate the secondary MICROGLIAl activation processes after spinal cord injury (SCI).Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4.Results: The results of glial cell quantification along the 4900-mm long injured spinal cord showed a significant increase in glial cell density percentage at day 2 as compared to other days. Whereas the highest increase in ED-1 immunoreactive cells (monocyte/phagocyte marker in rats) was observed at day 2 (23.15%) post-injury. Evaluation of cavity percentage showed a significant difference between weeks 3 and 4 post-injury groups. Conclusions: This study provides a new insight into the multiphase immune response to SCI, including cellular INFLAMMATION, MACROPHAGES/microglia activation, glial cell density, and cavitation. Better understanding of the inflammatory processes associated with acute SCI would permit the development of better therapeutic strategies.

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APA: Copy

ABDANIPOUR, ALIREZA, TIRAIHI, TAKI, TAHERI, TAHER, & KAZEMI, HADI. (2013). MICROGLIAL ACTIVATION IN RAT EXPERIMENTAL SPINAL CORD INJURY MODEL. IRANIAN BIOMEDICAL JOURNAL, 17(4), 214-220. SID. https://sid.ir/paper/277360/en

Vancouver: Copy

ABDANIPOUR ALIREZA, TIRAIHI TAKI, TAHERI TAHER, KAZEMI HADI. MICROGLIAL ACTIVATION IN RAT EXPERIMENTAL SPINAL CORD INJURY MODEL. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2013;17(4):214-220. Available from: https://sid.ir/paper/277360/en

IEEE: Copy

ALIREZA ABDANIPOUR, TAKI TIRAIHI, TAHER TAHERI, and HADI KAZEMI, “MICROGLIAL ACTIVATION IN RAT EXPERIMENTAL SPINAL CORD INJURY MODEL,” IRANIAN BIOMEDICAL JOURNAL, vol. 17, no. 4, pp. 214–220, 2013, [Online]. Available: https://sid.ir/paper/277360/en

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