مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

480
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

184
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

THE EFFECT OF ASCORBIC ACID AND GARLIC ADMINISTRATION ON LEAD-INDUCED APOPTOSIS IN RAT OFFSPRING’S EYE RETINA

Pages

  206-213

Abstract

 Introduction: LEAD toxicity induces RETINAl cell APOPTOSIS. Vitamin C and GARLIC may decrease LEAD-induced APOPTOSIS. This study was undertaken to investigate vitamin C and GARLIC protective effects on LEAD-induced APOPTOSIS in eye RETINA.Methods: Pregnant Wistar rats (n=72) were divided randomly into 9 groups: (L) treated rats with LEAD acetate in drinking water and (L+AA) with LEADed water and vitamin C intraperitoneally; (L+G), the rats received LEADed-water and GARLIC juice via gavage; (L+AA+G) treated rats with LEADed water, ASCORBIC ACID, and GARLIC juice, (AA) with ASCORBIC ACID, and (G) with GARLIC juice; (AA+G) treated rats with vitamin C and GARLIC juice and (Sh) with tap water plus normal hydrogen chloride (HCl) and glucose; normal (N). After 21-day lactation, blood LEAD level (BLL) in rats was measured, and then their offspring and the rat offspring’s eyes were removed and processed for using TUNEL method. TUNEL positive cells in the eye RETINA were counted and all groups were compared.Results: BLL increased in L group compared to the control groups and decreased significantly in L+G, L+AA, and L+AA+G groups compared to L group (P<0.05). TUNELL positive cell number in eye RETINA significantly increased in L group compared to control groups (P<0.05) and decreased in L+G, L+AA, and L+AA +G groups compared to L group (P<0.05).Conclusion: GARLIC juice and ASCORBIC ACID administration during pregnancy and lactation may protect LEAD-induced APOPTOSIS in rat offspring’s eye RETINA.

Cites

References

  • No record.

    • Cite

    APA: Copy

    KHORDAD, ELNAZ, FAZEL, ALIREZA, & EBRAHIMZADEH BIDESKAN, ALIREZA. (2013). THE EFFECT OF ASCORBIC ACID AND GARLIC ADMINISTRATION ON LEAD-INDUCED APOPTOSIS IN RAT OFFSPRING’S EYE RETINA. IRANIAN BIOMEDICAL JOURNAL, 17(4), 206-213. SID. https://sid.ir/paper/277365/en

    Vancouver: Copy

    KHORDAD ELNAZ, FAZEL ALIREZA, EBRAHIMZADEH BIDESKAN ALIREZA. THE EFFECT OF ASCORBIC ACID AND GARLIC ADMINISTRATION ON LEAD-INDUCED APOPTOSIS IN RAT OFFSPRING’S EYE RETINA. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2013;17(4):206-213. Available from: https://sid.ir/paper/277365/en

    IEEE: Copy

    ELNAZ KHORDAD, ALIREZA FAZEL, and ALIREZA EBRAHIMZADEH BIDESKAN, “THE EFFECT OF ASCORBIC ACID AND GARLIC ADMINISTRATION ON LEAD-INDUCED APOPTOSIS IN RAT OFFSPRING’S EYE RETINA,” IRANIAN BIOMEDICAL JOURNAL, vol. 17, no. 4, pp. 206–213, 2013, [Online]. Available: https://sid.ir/paper/277365/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button