مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

314
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

165
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN P53 CODON 72 (ARG72PRO) POLYMORPHISM AND PRIMARY OPEN-ANGLE GLAUCOMA IN IRANIAN PATIENTS

Pages

  51-56

Keywords

PRIMARY OPEN-ANGLE GLAUCOMA (POAG) 
P53 

Abstract

 Background: GLAUCOMAtous neuropathy is a type of cell death due to apoptosis. The P53 gene is one of the regulatory genes of apoptosis. Recently, the association between thep53 gene encoding for proline at CODON 72 and primary open-angle GLAUCOMA (POAG) has been studied in some ethnic groups. This study is the first association analysis of POAG and P53 CODON 72 polymorphism in IRANian patients.Methods: A cohort of 65 unrelated patients with POAG (age range from 12-62 years, mean ± SD of 40.16 ± 17.51 years) and 65 unrelated control subjects (without GLAUCOMA, age range of 14-63 years, mean ± SD of 35.64 ± 13.61 years) were selected. In IRANian POAG patients and normal healthy controls, the P53 CODON 72 polymorphism in exon 4 was amplified using polymerase chain reaction. The amplified DNA fragments were digested with the BstUI restriction enzyme, and the digestion patterns were used to identify the alleles for the polymorphic site.Results: Comparisons revealed significant differences in allele and genotype frequencies of Pro72Arg between POAG patients and control group. A higher risk of POAG was associated with allele Pro (OR=2.1, 95% CI=1.2-3.4) and genotype Pro/Pro (OR=3.9, 95% CI=0.13-12.7).Conclusion: The P53 Pro72 allele was more frequent in IRANian POAG patients than in the control group (P<0.05). The present findings show that the individuals with the Pro/Pro genotype may be more likely to develop POAG. However, additional studies are necessary to confirm this association.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    NEAMATZADEH, HOSSEIN, SOLEIMANIZAD, REZA, ZARE SHEHNEH, MASOUD, GHARIBI, SABA, SHEKARI, ABOLFAZL, & RAHIMZADEH, AMIR BAHMAN. (2015). ASSOCIATION BETWEEN P53 CODON 72 (ARG72PRO) POLYMORPHISM AND PRIMARY OPEN-ANGLE GLAUCOMA IN IRANIAN PATIENTS. IRANIAN BIOMEDICAL JOURNAL, 19(1), 51-56. SID. https://sid.ir/paper/277391/en

    Vancouver: Copy

    NEAMATZADEH HOSSEIN, SOLEIMANIZAD REZA, ZARE SHEHNEH MASOUD, GHARIBI SABA, SHEKARI ABOLFAZL, RAHIMZADEH AMIR BAHMAN. ASSOCIATION BETWEEN P53 CODON 72 (ARG72PRO) POLYMORPHISM AND PRIMARY OPEN-ANGLE GLAUCOMA IN IRANIAN PATIENTS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(1):51-56. Available from: https://sid.ir/paper/277391/en

    IEEE: Copy

    HOSSEIN NEAMATZADEH, REZA SOLEIMANIZAD, MASOUD ZARE SHEHNEH, SABA GHARIBI, ABOLFAZL SHEKARI, and AMIR BAHMAN RAHIMZADEH, “ASSOCIATION BETWEEN P53 CODON 72 (ARG72PRO) POLYMORPHISM AND PRIMARY OPEN-ANGLE GLAUCOMA IN IRANIAN PATIENTS,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 1, pp. 51–56, 2015, [Online]. Available: https://sid.ir/paper/277391/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button