PREVALENCE OF CLASS 1 INTEGRONS AND EXTENDED SPECTRUM BETA LACTAMASES AMONG MULTI-DRUG RESISTANT ESCHERICHIA COLI ISOLATES FROM NORTH OF IRAN

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MEHDIPOUR MOGHADDAM MOHAMMAD JAVAD; ALSADAT MIRBAGHERI ADELEH; SALEHI ZIVAR; HABIBZADE SEYYED MAHMOOD

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:4 Page(s): 233-239

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Title

PREVALENCE OF CLASS 1 INTEGRONS AND EXTENDED SPECTRUM BETA LACTAMASES AMONG MULTI-DRUG RESISTANT ESCHERICHIA COLI ISOLATES FROM NORTH OF IRAN

Author(s)

MEHDIPOUR MOGHADDAM MOHAMMAD JAVAD | ALSADAT MIRBAGHERI ADELEH | SALEHI ZIVAR | HABIBZADE SEYYED MAHMOOD | Issue Writer Certificate

Keywords

ANTIBIOTIC

INTEGRONS

ESCHERICHIA COLI

Abstract

Background: Extended spectrum beta lactamases (ESBLs) are an important cause of transferable multidrug resistance (MDR) in gram-negative bacteria. The most described ESBL genes are generally found within integronlike structures as mobile genetic elements. The aim of this study was to identify the accompanying of class 1 INTEGRONS and ESBLs in the MDR E. coli isolates. Methods: Susceptibility to antimicrobial agents was determined for 33 E. coli strains by the disk diffusion method. Double-disk synergy test was applied for screening ESBL. To identify the strains carrying INTEGRONS, the conserved regions of integron-encoded integrase gene intI1 were amplified. For detection of gene cassettes, 5′CS and 3′CS primers were used. Results: All E. coli isolates were identified as multi-drug resistant. More than 50% of the isolates were resistant to tetracycline, cephalothin, cefuroxime, amoxicillin-clavulanic acid, and third generation cephalosporines. Nearly all of the isolates displayed sensitivity to piperacillin. There was a significant correlation between production of ESBL and resistance to all ANTIBIOTICs except for ciprofloxacin and piperacillin (P < 0.01). Thirty two MDR strains (97%) included class 1 integron, and some isolates that included INTEGRONS were similar in the size of gene cassettes. The isolates were different in the resistance profiles; however, some others had similar resistance profiles. Of eight ESBL positive isolates, seven (87.5%) carried class 1 INTEGRONS. Conclusion: Class 1 INTEGRONS were frequent in MDR and also ESBL-producing E. coli isolates. High prevalence of class 1 INTEGRONS confirms that integron-mediated antimicrobial gene cassettes are important in E. coli resistance profile.

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APA: Copy

MEHDIPOUR MOGHADDAM, MOHAMMAD JAVAD, ALSADAT MIRBAGHERI, ADELEH, SALEHI, ZIVAR, & HABIBZADE, SEYYED MAHMOOD. (2015). PREVALENCE OF CLASS 1 INTEGRONS AND EXTENDED SPECTRUM BETA LACTAMASES AMONG MULTI-DRUG RESISTANT ESCHERICHIA COLI ISOLATES FROM NORTH OF IRAN. IRANIAN BIOMEDICAL JOURNAL, 19(4), 233-239. SID. https://sid.ir/paper/277437/en

Vancouver: Copy

MEHDIPOUR MOGHADDAM MOHAMMAD JAVAD, ALSADAT MIRBAGHERI ADELEH, SALEHI ZIVAR, HABIBZADE SEYYED MAHMOOD. PREVALENCE OF CLASS 1 INTEGRONS AND EXTENDED SPECTRUM BETA LACTAMASES AMONG MULTI-DRUG RESISTANT ESCHERICHIA COLI ISOLATES FROM NORTH OF IRAN. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(4):233-239. Available from: https://sid.ir/paper/277437/en

IEEE: Copy

MOHAMMAD JAVAD MEHDIPOUR MOGHADDAM, ADELEH ALSADAT MIRBAGHERI, ZIVAR SALEHI, and SEYYED MAHMOOD HABIBZADE, “PREVALENCE OF CLASS 1 INTEGRONS AND EXTENDED SPECTRUM BETA LACTAMASES AMONG MULTI-DRUG RESISTANT ESCHERICHIA COLI ISOLATES FROM NORTH OF IRAN,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 4, pp. 233–239, 2015, [Online]. Available: https://sid.ir/paper/277437/en

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