CAN PREOPERATIVE CA-125 PREDICT RESECTABILITY OF TUMOR IN PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA?

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MODARES GILANI M.; GHAEM MAGHAMI FATEMEH; ANSARIPOUR S.; SHARIAT M.; ZAERI F.

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2004 | Volume:42 | Issue:6 Page(s): 419-423

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Title

CAN PREOPERATIVE CA-125 PREDICT RESECTABILITY OF TUMOR IN PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA?

Author(s)

Keywords

PREOPERATIVE CA-125

RESECTABILITY

EPITHELIAL OVARIAN CARCINOMA

Abstract

Larger tumor burden leads to higher serum CA-125 levels and the ability to perform optimal tumor cytoreduction of advanced ovarian cancer is also a function of tumor bulk. The purpose of this study was to identify the ability of preoperative serum CA-125 to predict possibility of optimal primary tumor cytoreduction in EPITHELIAL OVARIAN CARCINOMA (EOC). A total of 90 patients with EOC were evaluated in a prospective study from 2000 to 2002. Preoperative serum CA-125 levels were determined, using a solid phase immunoassay. We used a receiver operating characteristic curve to identify the CA-125 level with the maximal prognostic power in predicting optimal versus suboptimal debulking. The median CA-125 level for the 90 patients was 500 U/ml (range 13 to 5000 U/ml). Seventy patient (78%) had stage III or ?V based on staging system of the International Federation of Gynecology and Obstetrics (FIGO) for ovarian carcinoma. Optimal cytoreduction (diameter of largest residual tumor less than 1 cm) was obtained in 44 patients (62.9%) with stage III-?V. Preoperative CA- 125 value less than 450 U/ml had a positive predictive value for optimal cytoreduction of 78%, but a poor negative predictive value of 50% in advanced EOC. In patients with advanced EOC, at a cutoff 450 U/ml, 78% underwent optimal debulking, whereas 50% of patients with PREOPERATIVE CA-125 level above 450 U/ml were still able to undergo optimal debulking. PREOPERATIVE CA-125 does not seem to be a reliable predictor of optimal cytoreduction.

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APA: Copy

MODARES GILANI, M., GHAEM MAGHAMI, FATEMEH, ANSARIPOUR, S., SHARIAT, M., & ZAERI, F.. (2004). CAN PREOPERATIVE CA-125 PREDICT RESECTABILITY OF TUMOR IN PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA?. ACTA MEDICA IRANICA, 42(6), 419-423. SID. https://sid.ir/paper/277540/en

Vancouver: Copy

MODARES GILANI M., GHAEM MAGHAMI FATEMEH, ANSARIPOUR S., SHARIAT M., ZAERI F.. CAN PREOPERATIVE CA-125 PREDICT RESECTABILITY OF TUMOR IN PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA?. ACTA MEDICA IRANICA[Internet]. 2004;42(6):419-423. Available from: https://sid.ir/paper/277540/en

IEEE: Copy

M. MODARES GILANI, FATEMEH GHAEM MAGHAMI, S. ANSARIPOUR, M. SHARIAT, and F. ZAERI, “CAN PREOPERATIVE CA-125 PREDICT RESECTABILITY OF TUMOR IN PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA?,” ACTA MEDICA IRANICA, vol. 42, no. 6, pp. 419–423, 2004, [Online]. Available: https://sid.ir/paper/277540/en

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