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Information Journal Paper

Title

LDL SUBCLASS PATTERNS AND ATHEROGENICITY IN NON-INSULIN DEPENDENT DIABETES MELLITUS

Author(s)

 KAZEROUNI F. | JAVADI E. | DOUSTI M. | ARDESHIR LARIJANI MOHAMMAD BAGHER | Issue Writer Certificate 

Pages

  325-330

Abstract

 Low density lipoprotein (LDL) subclass PATTERN B is characterized by predominance of small dense LDL. Subjects with PATTERN B tend to have higher TRIGLYCERIDE (TG) and lower levels of high density lipoprotein cholesterol (HDL-C). Small dense LDL is associated with increased risk of coronary disease. In this study, effect of NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) on LDL size, plasma TG and HDL-C were assessed in Iranian patients. LDL size was determined by non-denaturing gradient polyacrylamide gel electrophoresis in 81 NIDDM and 81 healthy subjects (age 50 to 70 yrs). TG and HDL-C were measured by analytical kits. Fifty nine percent of diabetics and 27% of controls showed LDL pattern B. LDL size was significantly lower in diabetics than controls (25.1± 1.5 vs 25.8± 2.8 nm, P<0.001). Diabetics had significantly higher TRIGLYCERIDE than controls (187.8 ± 90 vs 145.6 ± 69 mg/dl, P<0.001) and lower HDL-C (47.5± 12 vs 57.1± 14 mg/dl, P<0.001). LDL size correlated negatively with TG (r = -0.281, P<0.05). Diabetics showed 2-fold increase in frequency of PATTERN B which may explain increased risk of coronary disease in these patients.

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    APA: Copy

    KAZEROUNI, F., JAVADI, E., DOUSTI, M., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2004). LDL SUBCLASS PATTERNS AND ATHEROGENICITY IN NON-INSULIN DEPENDENT DIABETES MELLITUS. ACTA MEDICA IRANICA, 42(5), 325-330. SID. https://sid.ir/paper/277561/en

    Vancouver: Copy

    KAZEROUNI F., JAVADI E., DOUSTI M., ARDESHIR LARIJANI MOHAMMAD BAGHER. LDL SUBCLASS PATTERNS AND ATHEROGENICITY IN NON-INSULIN DEPENDENT DIABETES MELLITUS. ACTA MEDICA IRANICA[Internet]. 2004;42(5):325-330. Available from: https://sid.ir/paper/277561/en

    IEEE: Copy

    F. KAZEROUNI, E. JAVADI, M. DOUSTI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “LDL SUBCLASS PATTERNS AND ATHEROGENICITY IN NON-INSULIN DEPENDENT DIABETES MELLITUS,” ACTA MEDICA IRANICA, vol. 42, no. 5, pp. 325–330, 2004, [Online]. Available: https://sid.ir/paper/277561/en

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