PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN TYPE I DIABETES MELLITUS

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MOAYERI H.; RABANI ALI

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Journal: ACTA MEDICA IRANICA Year:2004 | Volume:42 | Issue:4 Page(s): 267-271

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Information Journal Paper

Title

PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN TYPE I DIABETES MELLITUS

Author(s)

MOAYERI H. | RABANI ALI | Issue Writer Certificate

Keywords

AUTOIMMUNE THYROID DISEASE

ANTI PEROXIDASE ANTIBODY

DIABETES MELLITUS TYPE I

Abstract

Type I diabetes mellitus (DM) is frequently associated with AUTOIMMUNE THYROID DISEASE (ATD). Association of ATD and type I DM has been described with varying frequencies but there is still debate about the situation in the Iranian population. We investigated the prevalence of anti thyroid peroxidase (anti-TPO) antibodies and ATD in children and adolescents with type I DM. A total of 145 patients with type I DM were participated in this study. They were screened for anti-TPO antibodies and TSH levels. Signs and symptoms of hypothyroidism and hyperthyroidism and the presence of goiter were sought. A group of 50 healthy unrelated girls and boys aged 11-16 years served as controls. Anti-TPO antibodies were found in 34 (23.4%) diabetic patients and 1 subject (2%) in the control group (P<0.001). Frequency of anti TPO antibodies was significantly higher in girls than boys (P<0.05). We failed to show any significant correlation between thyroid autoimmunity and duration of DM. We found that younger patients at diagnosis are more likely to be anti-TPO negative (P<0.001). Out of 145 diabetic patients, 32 (22%) had visible goiter. Subclinical hypothyroidism, hypothyroidism and thyrotoxicosis occurred in 1, 9 and 1 patients, respectively. Visible goiter was found in 2 subjects (4%) of the control group, but all of them were euthyroid. In conclusion, the evaluation of thyroid autoimmunity in type I diabetic patients may improve the diagnosis of thyroid disease in early stages. Yearly examination of anti-TPO antibodies allows identifying diabetic patients with thyroid autoimmunity.

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APA: Copy

MOAYERI, H., & RABANI, ALI. (2004). PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN TYPE I DIABETES MELLITUS. ACTA MEDICA IRANICA, 42(4), 267-271. SID. https://sid.ir/paper/277575/en

Vancouver: Copy

MOAYERI H., RABANI ALI. PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN TYPE I DIABETES MELLITUS. ACTA MEDICA IRANICA[Internet]. 2004;42(4):267-271. Available from: https://sid.ir/paper/277575/en

IEEE: Copy

H. MOAYERI, and ALI RABANI, “PREVALENCE OF AUTOANTIBODIES TO THYROID PEROXIDASE AND AUTOIMMUNE THYROID DISEASE IN TYPE I DIABETES MELLITUS,” ACTA MEDICA IRANICA, vol. 42, no. 4, pp. 267–271, 2004, [Online]. Available: https://sid.ir/paper/277575/en

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