EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE

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SHIRI Y.; AGHA ALINEJAD H.; GHARAKHANLOU R.; AMANI SHALAMZARI S.; SAEI M.A.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2014 | Volume:16 | Issue:3 Page(s): 205-210

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Title

EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE

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Keywords

BREAST CANCERQ2

ENDURANCE TRAININGQ2

INTERLEUKINQ2

10Q2

TUMOR VOLUMEQ2

Abstract

Methods: The twenty female Balb/c mice (6-8 week-old, 14±2 gr weights) were divided to two control and exercise groups. After orientation in the environment, estrogen-receptor dependent BREAST CANCER cells (MC4-L2) were injected to them and exercise group performed endurance exercise for 6 weeks. After appearance of the tumor, the length and width of the tumor were measured by a digital caliper once a week. Finally, the mice were sacrificed; tumor tissue was removed and immediately frozen and kept in -70oC. Tumor sample was homogenized and levels of IL-10 were measured and quantified using ELISA method.Results: There was significant increase on level of IL-10 in exercise group than control group (P£0.05). TUMOR VOLUME reduced in exercise group than control group. The results showed that the amount of IL-10 significantly increased in the exercise group compared to control group Also reduction in TUMOR VOLUME observed in the exercise group compared to control group. Conclusion: Increased levels of IL-10 was in parallel to reduction in TUMOR VOLUME, which shows that exercise lead to reduction tumor growth through increased levels of this cytokine. Angiogenesis is a prerequisite for continued growth and spread of tumors, therefore, increased levels of IL-10 that is an angiogenesis cytokine in the exercise group compared to the control group shows exercise can inhibit from tumor growth by modulating cytokine profile within the tumor microenvironment.

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APA: Copy

SHIRI, Y., AGHA ALINEJAD, H., GHARAKHANLOU, R., AMANI SHALAMZARI, S., & SAEI, M.A.. (2014). EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(3), 205-210. SID. https://sid.ir/paper/27772/en

Vancouver: Copy

SHIRI Y., AGHA ALINEJAD H., GHARAKHANLOU R., AMANI SHALAMZARI S., SAEI M.A.. EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2014;16(3):205-210. Available from: https://sid.ir/paper/27772/en

IEEE: Copy

Y. SHIRI, H. AGHA ALINEJAD, R. GHARAKHANLOU, S. AMANI SHALAMZARI, and M.A. SAEI, “EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 3, pp. 205–210, 2014, [Online]. Available: https://sid.ir/paper/27772/en

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