INTRATUMORAL EFFECTS OF CONTINUOUS ENDURANCE TRAINING AND HIGH INTENSITY INTERVAL TRAINING ON GENES EXPRESSION OF MIR-21 AND BCL-2 IN BREAST CANCER BEARING FEMALE MICE

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DELPHAN M.; AGHA ALINEJAD H.; DELFAN M.; DEHGHAN S.

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Journal: Iranian Journal of Breast Diseases Year:2017 | Volume:10 | Issue:2 Page(s): 49-57

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Title

INTRATUMORAL EFFECTS OF CONTINUOUS ENDURANCE TRAINING AND HIGH INTENSITY INTERVAL TRAINING ON GENES EXPRESSION OF MIR-21 AND BCL-2 IN BREAST CANCER BEARING FEMALE MICE

Author(s)

DELPHAN M. | AGHA ALINEJAD H. | DELFAN M. | DEHGHAN S. | Issue Writer Certificate

Keywords

HIGH INTENSITY INTERVAL TRAININGQ2

CONTINUOUS ENDURANCE TRAININGQ2

MIR-21Q2

BCL-2Q2

BREAST CANCERQ2

Abstract

Introduction: Apoptosis and tumor growth are inhibited by intratumoral MIR-21 via upregulation of BCL-2. Hence, the aim of the present study was determine the effects of CONTINUOUS ENDURANCE TRAINING (ET) and HIGH INTENSITY INTERVAL TRAINING (HIIT) on intratumoral MIR-21 and BCL-2 of BREAST CANCER bearing female mice.Methods: Eighteen female BALB/c mice after inducing BREAST CANCER through MC4-L2 cell lines injection were randomly divided into three groups (n=6) including control, CONTINUOUS ENDURANCE TRAINING (ET) and HIGH INTENSITY INTERVAL TRAINING (HIIT). Then, both experimental groups including ET (75 min/day, constant running speed corresponding to 60–65%) and HIIT (six intervals for 3 min and 20 seconds, 85-90% 2 peak, 90 second of active rest at 30-35% 2 peak separating intervals) performed exercise protocols at 15% inclination, five days a week for ten weeks. Tumor volume was measured and recorded by caliper every week. MIR-21 and BCL-2 gene expression were determined by qReal-time PCR. Statistic data values also were measured by One-way ANOVA.Results: The results of the present study showed that MIR-21 gene expression was significantly reduced in both experimental groups compared to control group (p£0.001). While, BCL-2 gene expression had no significant change in comparison with control group (p³0.05). There was also observed a significant reduction in tumor volume of two experimental groups in comparison with control group. It should be noted that tumor volume reduction in HIIT was larger than ET.Conclusion: HIIT is possibly more effective than ET in attenuating cancer cells progression via its intratumoral effects.

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APA: Copy

DELPHAN, M., AGHA ALINEJAD, H., DELFAN, M., & DEHGHAN, S.. (2017). INTRATUMORAL EFFECTS OF CONTINUOUS ENDURANCE TRAINING AND HIGH INTENSITY INTERVAL TRAINING ON GENES EXPRESSION OF MIR-21 AND BCL-2 IN BREAST CANCER BEARING FEMALE MICE. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 10(2), 49-57. SID. https://sid.ir/paper/144611/en

Vancouver: Copy

DELPHAN M., AGHA ALINEJAD H., DELFAN M., DEHGHAN S.. INTRATUMORAL EFFECTS OF CONTINUOUS ENDURANCE TRAINING AND HIGH INTENSITY INTERVAL TRAINING ON GENES EXPRESSION OF MIR-21 AND BCL-2 IN BREAST CANCER BEARING FEMALE MICE. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2017;10(2):49-57. Available from: https://sid.ir/paper/144611/en

IEEE: Copy

M. DELPHAN, H. AGHA ALINEJAD, M. DELFAN, and S. DEHGHAN, “INTRATUMORAL EFFECTS OF CONTINUOUS ENDURANCE TRAINING AND HIGH INTENSITY INTERVAL TRAINING ON GENES EXPRESSION OF MIR-21 AND BCL-2 IN BREAST CANCER BEARING FEMALE MICE,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 10, no. 2, pp. 49–57, 2017, [Online]. Available: https://sid.ir/paper/144611/en

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