THE EFFECT OF ACUTE LITHIUM AND AMI-193, A NEW 5HT2 ANTAGONIST, ON APOMORPHINE-INDUCED PECKING IN PIGEON

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BAGHERI T.; EJTEMAEIMEHR SH.; SHAMSHIRGARAN SH.

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Journal: ACTA MEDICA IRANICA Year:2002 | Volume:40 | Issue:2 Page(s): 109-114

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Title

THE EFFECT OF ACUTE LITHIUM AND AMI-193, A NEW 5HT2 ANTAGONIST, ON APOMORPHINE-INDUCED PECKING IN PIGEON

Author(s)

BAGHERI T. | EJTEMAEIMEHR SH. | SHAMSHIRGARAN SH. | Issue Writer Certificate

Keywords

PECKING

SEROTONIN RECEPTORS

APOMORPHINE

Abstract

Intramascular (IM) administration of APOMORPHINE (a mixed D1/D2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. In this study the effect of lithium (Li+, 240 mg/kg, IM) and AMI-193 (a new 5-HT2 antagonist, 0.003 mg/pigeon) on APOMORPHINE-induced peking (AIP) were investigated. This study showed that Li+ and AMI-193 did not induce PECKING by itself but administration of each of these agents before APOMORPHINE increased and decreased the AIP (apomor-phine 0.8 mg/kg) respectively whereas concomitant use of Li+ (240 mg/kg IM) and AMI-193 decreased AIP significantly. These results suggested that 5-HT2 antagonists inhibit the inhibitory effect of serotonin on the dopamine release in the raphe-striatal pathway but Li+ can modulate dopamine and serotonin function by different mechanisms and decrease this effect. As a result, it is mechanisms and decrease this effect. As a result, it is concluded serotonin can decrease the AIP through 5-HT2 receptors indirectly by decrease the dopamine release.

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APA: Copy

BAGHERI, T., EJTEMAEIMEHR, SH., & SHAMSHIRGARAN, SH.. (2002). THE EFFECT OF ACUTE LITHIUM AND AMI-193, A NEW 5HT2 ANTAGONIST, ON APOMORPHINE-INDUCED PECKING IN PIGEON. ACTA MEDICA IRANICA, 40(2), 109-114. SID. https://sid.ir/paper/277765/en

Vancouver: Copy

BAGHERI T., EJTEMAEIMEHR SH., SHAMSHIRGARAN SH.. THE EFFECT OF ACUTE LITHIUM AND AMI-193, A NEW 5HT2 ANTAGONIST, ON APOMORPHINE-INDUCED PECKING IN PIGEON. ACTA MEDICA IRANICA[Internet]. 2002;40(2):109-114. Available from: https://sid.ir/paper/277765/en

IEEE: Copy

T. BAGHERI, SH. EJTEMAEIMEHR, and SH. SHAMSHIRGARAN, “THE EFFECT OF ACUTE LITHIUM AND AMI-193, A NEW 5HT2 ANTAGONIST, ON APOMORPHINE-INDUCED PECKING IN PIGEON,” ACTA MEDICA IRANICA, vol. 40, no. 2, pp. 109–114, 2002, [Online]. Available: https://sid.ir/paper/277765/en

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