HARDY-WEINBERG LAW AND LINKAGE DISEQUILIBRIUM ANALYSIS IN THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE IN TEHRANIAN ADULTS

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DANESHPOUR M.A.S.; HEDAYATI MAHDI; AZIZI FEREYDOUN

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2005 | Volume:7 | Issue:SUPPLEMENT 4 Page(s): 399-403

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Title

HARDY-WEINBERG LAW AND LINKAGE DISEQUILIBRIUM ANALYSIS IN THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE IN TEHRANIAN ADULTS

Author(s)

DANESHPOUR M.A.S. | HEDAYATI MAHDI | AZIZI FEREYDOUN | Issue Writer Certificate

Keywords

CHOLESTEROL ESTER TRANSFER PROTEINQ4

POLYMORPHISMQ2

ALLELEQ3

HARDY-WEINBERG EQUILIBRIUMQ4

LINKAGE DISEQUILIBRIUMQ4

Abstract

Introduction: The aim of this study was to calculate the HARDY-WEINBERG EQUILIBRIUM in the TaqI and –629A/C POLYMORPHISMs in the CETP gene and analysis LINKAGE DISEQUILIBRIUM in B2 and A ALLELE. Materials and methods: 335 participants of the Tehran Lipid and Glucose Study were selected with the lowest, medium and highest deciles of HDL cholesterol levels. Genomic DNA were extracted and in the CETP gene a segment of the promoter and a segment of intron 1 were amplified and then incubated with restriction enzymes, Van19 I and TaqI respectively using the RFLP method. Results: The B2 ALLELE frequency of the TaqI POLYMORPHISM was 0.382 and A ALLELE of the -629A/C POLYMORPHISM was 0.462. The linkage analysis showed D=0.0965 and D′=0.4695. Conclusion: We demonstrated that B1 and B2 ALLELE frequency in intron1, and A and C ALLELE frequency in promoter of the mentioned gene was in disequilibrium in our population and that LINKAGE DISEQUILIBRIUM was seen between A and B2 ALLELE.

Cites

ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN

References

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APA: Copy

DANESHPOUR, M.A.S., HEDAYATI, MAHDI, & AZIZI, FEREYDOUN. (2005). HARDY-WEINBERG LAW AND LINKAGE DISEQUILIBRIUM ANALYSIS IN THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE IN TEHRANIAN ADULTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(SUPPLEMENT 4), 399-403. SID. https://sid.ir/paper/27800/en

Vancouver: Copy

DANESHPOUR M.A.S., HEDAYATI MAHDI, AZIZI FEREYDOUN. HARDY-WEINBERG LAW AND LINKAGE DISEQUILIBRIUM ANALYSIS IN THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE IN TEHRANIAN ADULTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(SUPPLEMENT 4):399-403. Available from: https://sid.ir/paper/27800/en

IEEE: Copy

M.A.S. DANESHPOUR, MAHDI HEDAYATI, and FEREYDOUN AZIZI, “HARDY-WEINBERG LAW AND LINKAGE DISEQUILIBRIUM ANALYSIS IN THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE IN TEHRANIAN ADULTS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. SUPPLEMENT 4, pp. 399–403, 2005, [Online]. Available: https://sid.ir/paper/27800/en

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