ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN

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DANESHPOUR M.A.S.; HEDAYATI MAHDI; AZIZI FEREYDOUN

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2005 | Volume:7 | Issue:SUPPLEMENT 4 Page(s): 387-391

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Title

ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN

Author(s)

DANESHPOUR M.A.S. | HEDAYATI MAHDI | AZIZI FEREYDOUN | Issue Writer Certificate

Keywords

CHOLESTEROL ESTER TRANSFER PROTEINQ4

POLYMORPHISMQ2

ALLELEQ3

TEHRANQ2

Abstract

Introduction: The aim of this study was to examine the relation between CETP activity and TaqI and -629A/C POLYMORPHISM and its effect on HDL-C level. Materials and Methods: 335 people from the TEHRAN Lipid and Glucose Study were selected with the lowest, medium and highest deciles of HDL cholesterol levels. Genomic DNA samples were extracted and in the CETP gene a segment of the promoter and a segment of intron 1 were amplified and then incubated with restriction enzymes, Van19 I and TaqI respectively using the RFLP method. 103 homozygote subjects were selected for measurement of CETP activity. Results: The B2 and A ALLELE presence was significantly associated with increased levels of HDL-C and decrease of CETP activity. (B1B1, 67.8±8.9 pmol/L; B2B2, 62.6±9.6 pmol/L; P 0.010) (CC, 68.6±8.4 pmol/L; AA, 62.7±9.7pmol/L; P 0.002)]. Conclusion: We demonstrated that the B2 ALLELE presence in TaqI POLYMORPHISM is associated with low CETP activity and high HDL-C; similar results can be seen in presence of the A ALLELE in –629A/C POLYMORPHISM.

Cites

COMPARISON OF PRECIPITATION AND DIRECT METHODS FOR HDL-C ASSAY

References

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APA: Copy

DANESHPOUR, M.A.S., HEDAYATI, MAHDI, & AZIZI, FEREYDOUN. (2005). ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(SUPPLEMENT 4), 387-391. SID. https://sid.ir/paper/27797/en

Vancouver: Copy

DANESHPOUR M.A.S., HEDAYATI MAHDI, AZIZI FEREYDOUN. ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(SUPPLEMENT 4):387-391. Available from: https://sid.ir/paper/27797/en

IEEE: Copy

M.A.S. DANESHPOUR, MAHDI HEDAYATI, and FEREYDOUN AZIZI, “ASSOCIATION BETWEEN CETP ACTIVITY AND THE TAQI AND –629A/C POLYMORPHISMS IN CETP GENE AND HDL-C LEVEL IN A POPULATION OF TEHRAN,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. SUPPLEMENT 4, pp. 387–391, 2005, [Online]. Available: https://sid.ir/paper/27797/en

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