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Information Journal Paper

Title

CORRELATION BETWEEN PROGNOSIS AND RESPONSE TO TREATMENT IN CHILDREN WITH FSGS

Pages

  93-96

Abstract

 To determine the prognostic value of response to treatment in patients with FOCAL SEGMENTAL glomerulo- sclerosis. FSGS includes 10-15% of idiopathic NEPHROTIC SYNDROME in CHILDREN. Bulk of evidence supports disease relationship with immune system. Unfortunately, responses to immunosuppressive drugs are not desirable and progression to end-stage renal disease is common. We analyzed 62 out of 99 cases of biopsy proven idiopathic FSGS who were followed for at least 5-years or until renal failure occurred during study. Study design was historical cohort and patients were divided into two groups: exposed (resistant to treatment) and non-exposed (responsive to treatment). Correlation between PROGNOSIS and response to treatment was statistically evaluated. P-value (0.05 and relative risk ( 1 was considered significant. In 3 out of 25 steroid responsive patients (12%) and 22 out of 37 steroid resistant patients (59.5%), disease progressed to renal failure.Disease progressed to renal failure in 2 out of 11 cyclophosphamide responsive patients (18.1%), 17 out of 23 cyclophosphamide resistant patients (74.3%), and 8 out of 14 cyclosporine resistant patients (57.1%). 2 patients who responded to cyclosporine had normal renal function at the time of the last follow up. We concluded that favorable response to steroid and cyclophosphamide treatment is a protective factor against disease progression to end stage renal disease and resistance to these drugs imply a poor PROGNOSIS. For making any definite conclusion concerning response to cyclosporine treatment and PROGNOSIS, similar studies with a larger sample are required.

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    APA: Copy

    NASERI, M., MADANI, ABAS, & ATAEI, N.A.. (2009). CORRELATION BETWEEN PROGNOSIS AND RESPONSE TO TREATMENT IN CHILDREN WITH FSGS. ACTA MEDICA IRANICA, 47(2), 93-96. SID. https://sid.ir/paper/278205/en

    Vancouver: Copy

    NASERI M., MADANI ABAS, ATAEI N.A.. CORRELATION BETWEEN PROGNOSIS AND RESPONSE TO TREATMENT IN CHILDREN WITH FSGS. ACTA MEDICA IRANICA[Internet]. 2009;47(2):93-96. Available from: https://sid.ir/paper/278205/en

    IEEE: Copy

    M. NASERI, ABAS MADANI, and N.A. ATAEI, “CORRELATION BETWEEN PROGNOSIS AND RESPONSE TO TREATMENT IN CHILDREN WITH FSGS,” ACTA MEDICA IRANICA, vol. 47, no. 2, pp. 93–96, 2009, [Online]. Available: https://sid.ir/paper/278205/en

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