EFFECTS OF ORAL SODIUM NITRATE ADMINISTRATION ON CELL BLOOD COUNT IN OBESE TYPE 2 DIABETIC MALE RATS

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KHORASANY V.; YAGHMEAI P.; TOHIDI M.; GHEIBI S.; VARZANDI T.; GHASEMI A.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2018 | Volume:19 | Issue:5 Page(s): 340-348

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Title

EFFECTS OF ORAL SODIUM NITRATE ADMINISTRATION ON CELL BLOOD COUNT IN OBESE TYPE 2 DIABETIC MALE RATS

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Keywords

TYPE 2 DIABETESQ2

NITRATEQ2

CELL BLOOD COUNTQ1

MALE RATQ2

Abstract

Introduction: TYPE 2 DIABETES is one of the most common metabolic diseases. NITRATE has been introduced as a new therapeutic agent for TYPE 2 DIABETES. Considering that both diabetes and NITRATE have some effects on blood cell count and 30% of diabetic patients have anemia, the aim of this study was to determine the effect of sodium NITRATE on blood cell count in obese type 2 diabetic rats. Materials and Methods: Forty-eight male Wistar rats were divided into four groups: Control, Control+nitrate, Diabetes and Diabetes+nitrate. The groups that received NITRATE (Control +nitrate, Diabetes+nitrate) again were divided into two subgroups, which received sodium NITRATE (100 and 250 mg/L in drinking water) for two months: control+nitrate100 (CN100), control+nitrate 250 (CN250), diabetes+nitrate100 (DN100), and diabetes+nitrate250 (DN250). Diabetes was induced using a high-fat diet for 14 days and injection of streptozotocin. Blood cell count was performed at the end of the study.Results: In diabetic rats, NITRATE administration reduced body weight, blood glucose, hematocrits, and neutrophils (all p<0.05) but increased total number of white blood cells and lymphocytes (p<0.05). NITRATE administration had no effect on the number of red blood cells, hemoglobin concentration, MCV, MCH, MCHC, or platelet numbers.Conclusion: Administration of sodium NITRATE, which is considered as a therapeutic agent in TYPE 2 DIABETES, decreased blood glucose in the type 2 diabetic rats but had no major harmful effects on blood parameters; in addition, it may also have anti-inflammatory effects by decreasing the number of neutrophils.

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APA: Copy

KHORASANY, V., YAGHMEAI, P., TOHIDI, M., GHEIBI, S., VARZANDI, T., & GHASEMI, A.. (2018). EFFECTS OF ORAL SODIUM NITRATE ADMINISTRATION ON CELL BLOOD COUNT IN OBESE TYPE 2 DIABETIC MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 19(5 ), 340-348. SID. https://sid.ir/paper/27821/en

Vancouver: Copy

KHORASANY V., YAGHMEAI P., TOHIDI M., GHEIBI S., VARZANDI T., GHASEMI A.. EFFECTS OF ORAL SODIUM NITRATE ADMINISTRATION ON CELL BLOOD COUNT IN OBESE TYPE 2 DIABETIC MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;19(5 ):340-348. Available from: https://sid.ir/paper/27821/en

IEEE: Copy

V. KHORASANY, P. YAGHMEAI, M. TOHIDI, S. GHEIBI, T. VARZANDI, and A. GHASEMI, “EFFECTS OF ORAL SODIUM NITRATE ADMINISTRATION ON CELL BLOOD COUNT IN OBESE TYPE 2 DIABETIC MALE RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 19, no. 5 , pp. 340–348, 2018, [Online]. Available: https://sid.ir/paper/27821/en

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