DENDRITIC CELL STIMULATION BY IFN-β ALTERS T CELL FUNCTION VIA MODULATION OF CYTOKINE SECRETION IN DIABETES TYPE 1

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABEDIAN KENARI S.; GHASEMI MARYAM; ESLAMI M.B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ACTA MEDICA IRANICA Year:2009 | Volume:47 | Issue:5 Page(s): 341-347

Download Full-Text

View:

279

Download:

Cites:

Information Journal Paper

Title

DENDRITIC CELL STIMULATION BY IFN-β ALTERS T CELL FUNCTION VIA MODULATION OF CYTOKINE SECRETION IN DIABETES TYPE 1

Author(s)

ABEDIAN KENARI S. | GHASEMI MARYAM | ESLAMI M.B. | Issue Writer Certificate

Keywords

CYTOKINE

HLA-G

IFN-β (INTERFERON β)

DIABETES TYPE 1

AUTOIMMUNITY

DENDRITIC CELL

Abstract

During antigen capture and processing, mature DENDRITIC CELLs (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. We investigated the role of IFN-b in induction HLA-G expression on the monocyte derived DC and CYTOKINE profile in DIABETES TYPE 1. We accomplished secretary pattern and total CYTOKINE production of the Th1 CYTOKINE (IL-2, g IFN) and Th2 CYTOKINEs (IL-4, IL-10) before and after mixed leukocyte reaction (MLR) of 30 diabetic patients and 30 normal subjects. In this study a significant increase of IL-10 and gIFN reduction after IFN-b Therapy in culture in presence of HLA-G bearing DC as compared to control were seen. It is seen that DENDRITIC CELL causes IL-10 production of T cell in vitro that reduce T cell activation from diabetes patients and normal subjects resulted to the production and expression of HLA-G on these cells from both groups. Using mixed leukocyte reaction, it was found that IFN-b-treated DENDRITIC CELL mediated the inhibition of autologous T cell activation via IL-10 production and level of HLA-G on DENDRITIC CELL may be correlated to disease activity in diabetes patients and it could also serve as a useful marker for disease progress and treatment.

Cites

No record.

References

No record.

Cite

APA: Copy

ABEDIAN KENARI, S., GHASEMI, MARYAM, & ESLAMI, M.B.. (2009). DENDRITIC CELL STIMULATION BY IFN-β ALTERS T CELL FUNCTION VIA MODULATION OF CYTOKINE SECRETION IN DIABETES TYPE 1. ACTA MEDICA IRANICA, 47(5), 341-347. SID. https://sid.ir/paper/278292/en

Vancouver: Copy

ABEDIAN KENARI S., GHASEMI MARYAM, ESLAMI M.B.. DENDRITIC CELL STIMULATION BY IFN-β ALTERS T CELL FUNCTION VIA MODULATION OF CYTOKINE SECRETION IN DIABETES TYPE 1. ACTA MEDICA IRANICA[Internet]. 2009;47(5):341-347. Available from: https://sid.ir/paper/278292/en

IEEE: Copy

S. ABEDIAN KENARI, MARYAM GHASEMI, and M.B. ESLAMI, “DENDRITIC CELL STIMULATION BY IFN-β ALTERS T CELL FUNCTION VIA MODULATION OF CYTOKINE SECRETION IN DIABETES TYPE 1,” ACTA MEDICA IRANICA, vol. 47, no. 5, pp. 341–347, 2009, [Online]. Available: https://sid.ir/paper/278292/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops