THE INCIDENCE OF NOSOCOMIAL TOXIGENIC CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN TEHRAN TERTIARY MEDICAL CENTERS

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SADEGHIFARD NORAKHODA; SALARI MOHAMMAD HOSSEIN; GHASSEMI MOHAMMAD RAZA; ESHRAGHI SAEED; AMIN HARATI FARZANAH

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Journal: ACTA MEDICA IRANICA Year:2010 | Volume:48 | Issue:5 Page(s): 320-325

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Title

THE INCIDENCE OF NOSOCOMIAL TOXIGENIC CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN TEHRAN TERTIARY MEDICAL CENTERS

Author(s)

Keywords

NOSOCOMIAL INFECTION

DIARRHEA

CLOSTRIDIUM DIFFICIK

TOXINS

BIOLOGICAL

ANTIMICROBIAL SENSITIVITY

Abstract

Clostridium difficile is the most common cause of nosocomial DIARRHEA. It is usually a consequence of antibiotic treatment, But sporadic cases can occur. This study was aimed to determine the frequency of the nosocomial Clostridium difficile (C. difficile) associated DIARRHEA in Tehran University of Medical Sciences hospitals and study of antibacterial susceptibility of isolates. In this study a total of 942 stool samples from patients with nosocomial DIARRHEA that were hospitalized in Imam Khomeini hospital, Shariati hospital and Children clinical center were collected. The samples were cultured on a selective cycloserine cefoxitin fructose agar (CCFA) and incubated in anaerobic conditions, at 37oC for 5 days. Isolates were characterized to species level by conventional biochemical tests. Bacterial cytotoxicity was assayed on tissue culture (vero). ANTIMICROBIAL SENSITIVITY of isolated toxigenic C. difficile were investigated by kirby Beuer method (disk diffusion). Our findings show that, of the total patients, 57 toxigenic C. difficile (6.1%) were isolated. Results of statistical analysis show significant differences between the rate of isolated toxigenic C. difficile and age group of patients (P<0.05). Among the wards of selected hospitals, in gastroenterology of Children clinical center, Toxigenic C. difficile was isolated from patients most frequently. The sensitivity of isolates to vancomycin, Chloramphenicol and ceftriaxone were higher than other antibiotics. Toxigenic C. difficile is a common hospital-acquired infection. The organism was found in 6.1% hospitalized patients. Further studies to evaluate the rate and role of toxigenic C. difficile in nosocomial DIARRHEAl processes, ecological and pathogenic terms are suggested.

Cites

EFFECT OF PROBIOTIC PREPARATION IN PREVENTING ANTIBIOTIC ASSOCIATED DIARRHEA AND COLITIS: A CLINICAL TRIAL

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APA: Copy

SADEGHIFARD, NORAKHODA, SALARI, MOHAMMAD HOSSEIN, GHASSEMI, MOHAMMAD RAZA, ESHRAGHI, SAEED, & AMIN HARATI, FARZANAH. (2010). THE INCIDENCE OF NOSOCOMIAL TOXIGENIC CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN TEHRAN TERTIARY MEDICAL CENTERS. ACTA MEDICA IRANICA, 48(5), 320-325. SID. https://sid.ir/paper/278446/en

Vancouver: Copy

SADEGHIFARD NORAKHODA, SALARI MOHAMMAD HOSSEIN, GHASSEMI MOHAMMAD RAZA, ESHRAGHI SAEED, AMIN HARATI FARZANAH. THE INCIDENCE OF NOSOCOMIAL TOXIGENIC CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN TEHRAN TERTIARY MEDICAL CENTERS. ACTA MEDICA IRANICA[Internet]. 2010;48(5):320-325. Available from: https://sid.ir/paper/278446/en

IEEE: Copy

NORAKHODA SADEGHIFARD, MOHAMMAD HOSSEIN SALARI, MOHAMMAD RAZA GHASSEMI, SAEED ESHRAGHI, and FARZANAH AMIN HARATI, “THE INCIDENCE OF NOSOCOMIAL TOXIGENIC CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN TEHRAN TERTIARY MEDICAL CENTERS,” ACTA MEDICA IRANICA, vol. 48, no. 5, pp. 320–325, 2010, [Online]. Available: https://sid.ir/paper/278446/en

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