SINGLE-DOSE VERSUS MULTIPLE-DOSE CIPROFLOXACIN PLUS METRONIDAZOLE PROPHYLAXIS IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A RANDOMIZED CONTROLLED TRIAL

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HEIDARI BATENI ZHOOBIN; SHAHROKH HOSSEIN; SALIMI HORMOZ; SAFARI HOSSEIN; TABATABAI MEGHDAD; SAEDI DARIUSH

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Journal: ACTA MEDICA IRANICA Year:2014 | Volume:52 | Issue:9 Page(s): 664-670

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Title

SINGLE-DOSE VERSUS MULTIPLE-DOSE CIPROFLOXACIN PLUS METRONIDAZOLE PROPHYLAXIS IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A RANDOMIZED CONTROLLED TRIAL

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Keywords

TRANSRECTAL ULTRASONOGRAPHIC BIOPSY OF PROSTATE

ANTIBIOTIC PROPHYLAXIS

PROSTATE CANCER

Abstract

To investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (TRUS)-guided biopsy of the prostate. Patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacteriuria, urinary tract infection (UTI) without fever, fever and urinary septicemia. The single-dose group received one ciprofloxacin 500 mg tablet and two metronidazole 250 mg tablets at 2 hours before the biopsy, while the multiple-doses group received those every 12 hours from 3 days before the biopsy. One-hundred and sixty patients were evaluated in two groups and bacteriuria in urinalysis was encountered in 12 patients (15%) in the single-dose group and four patients (5%) in the multiple-dose group, with a significant difference (P=0.035). UTI without fever occurred in six patients (7.5%) in the single-dose group and one patient (1.25%) in the multiple-dose group, with no significant difference (borderline (P=0.053). After biopsy, three patients (3.75%) returned with fever due to UTI and bacteremia in the single-dose group and none in the multiple-dose group, but with no significant difference (P=0.08). Regarding non-infectious complications, there were no significant differences between the two groups. Using prophylactic antibiotics for prostate biopsy in multiple doses, and at least 3 days before the procedure significantly reduces the rate of bacteriuria compared with a single-dose regimen.

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APA: Copy

HEIDARI BATENI, ZHOOBIN, SHAHROKH, HOSSEIN, SALIMI, HORMOZ, SAFARI, HOSSEIN, TABATABAI, MEGHDAD, & SAEDI, DARIUSH. (2014). SINGLE-DOSE VERSUS MULTIPLE-DOSE CIPROFLOXACIN PLUS METRONIDAZOLE PROPHYLAXIS IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A RANDOMIZED CONTROLLED TRIAL. ACTA MEDICA IRANICA, 52(9), 664-670. SID. https://sid.ir/paper/278638/en

Vancouver: Copy

HEIDARI BATENI ZHOOBIN, SHAHROKH HOSSEIN, SALIMI HORMOZ, SAFARI HOSSEIN, TABATABAI MEGHDAD, SAEDI DARIUSH. SINGLE-DOSE VERSUS MULTIPLE-DOSE CIPROFLOXACIN PLUS METRONIDAZOLE PROPHYLAXIS IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A RANDOMIZED CONTROLLED TRIAL. ACTA MEDICA IRANICA[Internet]. 2014;52(9):664-670. Available from: https://sid.ir/paper/278638/en

IEEE: Copy

ZHOOBIN HEIDARI BATENI, HOSSEIN SHAHROKH, HORMOZ SALIMI, HOSSEIN SAFARI, MEGHDAD TABATABAI, and DARIUSH SAEDI, “SINGLE-DOSE VERSUS MULTIPLE-DOSE CIPROFLOXACIN PLUS METRONIDAZOLE PROPHYLAXIS IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A RANDOMIZED CONTROLLED TRIAL,” ACTA MEDICA IRANICA, vol. 52, no. 9, pp. 664–670, 2014, [Online]. Available: https://sid.ir/paper/278638/en

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