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Information Journal Paper

Title

BUPROPION IN ADULTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: A RANDOMIZED, DOUBLE-BLIND STUDY

Pages

  675-680

Abstract

 Attention-Deficit/Hyperactivity Disorder is one of the most common mental disorders in childhood, and it continues to ADULThood without proper treatment. Stimulants have been used in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) for many years, and the efficacy of methylphenidate in the treatment of ADULTs with ADHD has been proven to be acceptable according to meta-analysis studies. However, there are some concerns about stimulants. Finding other effective medications for the treatment of ADULT ADHD seems necessary. We hypothesized BUPROPION could be effective in the treatment of ADULT ADHD because some theoretical and experimental evidence exists to support efficacy of this medication. Forty-two patients with a diagnosis of ADHD, according to the revised fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, were randomized to receive 150mg/day BUPROPION or placebo for a 6- week double-blind, placebo-controlled clinical trial. Each patient filled the Conners' ADULT ADHD Rating Scales–Self-Report-Screening version (CAARS) before starting to take medication and in weeks 3 and 6 of the study. The mean score of the two groups receiving BUPROPION or placebo decreased over the 6 weeks. There was a significant difference between the two groups in CAARS score after 6 weeks. BUPROPION is more effective than placebo in the treatment of ADULTs with ADHD. BUPROPION can be an alternative medication for the treatment of ADULTs with ADHD as its clinical efficacy was proven by other studies.

Cites

References

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APA: Copy

HAMEDI, MEHDI, MOHAMMADI, MOHAMMAD REZA, GHALEIHA, ALI, KESHAVARZI, ZAHRA, JAFARINIA, MORTEZA, KERAMATFAR, RASOOL, ALIKHANI, ROSA, EHYAII, ABOLFAZL, & AKHONDZADEH, SHAHIN. (2014). BUPROPION IN ADULTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: A RANDOMIZED, DOUBLE-BLIND STUDY. ACTA MEDICA IRANICA, 52(9), 675-680. SID. https://sid.ir/paper/278649/en

Vancouver: Copy

HAMEDI MEHDI, MOHAMMADI MOHAMMAD REZA, GHALEIHA ALI, KESHAVARZI ZAHRA, JAFARINIA MORTEZA, KERAMATFAR RASOOL, ALIKHANI ROSA, EHYAII ABOLFAZL, AKHONDZADEH SHAHIN. BUPROPION IN ADULTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: A RANDOMIZED, DOUBLE-BLIND STUDY. ACTA MEDICA IRANICA[Internet]. 2014;52(9):675-680. Available from: https://sid.ir/paper/278649/en

IEEE: Copy

MEHDI HAMEDI, MOHAMMAD REZA MOHAMMADI, ALI GHALEIHA, ZAHRA KESHAVARZI, MORTEZA JAFARINIA, RASOOL KERAMATFAR, ROSA ALIKHANI, ABOLFAZL EHYAII, and SHAHIN AKHONDZADEH, “BUPROPION IN ADULTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: A RANDOMIZED, DOUBLE-BLIND STUDY,” ACTA MEDICA IRANICA, vol. 52, no. 9, pp. 675–680, 2014, [Online]. Available: https://sid.ir/paper/278649/en

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