URSODEOXYCHOLIC ACID CAN IMPROVE LIVER TRANSAMINASE QUANTITIES IN CHILDREN WITH ANTICONVULSANT DRUGS HEPATOTOXICITY: A PILOT STUDY

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ASGARSHIRAZI MASOUMEH; SHARIAT MAMAK; DALILI HOSEIN; KEIHANIDOOST ZARRIN

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Journal: ACTA MEDICA IRANICA Year:2015 | Volume:53 | Issue:6 Page(s): 351-355

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Title

URSODEOXYCHOLIC ACID CAN IMPROVE LIVER TRANSAMINASE QUANTITIES IN CHILDREN WITH ANTICONVULSANT DRUGS HEPATOTOXICITY: A PILOT STUDY

Author(s)

ASGARSHIRAZI MASOUMEH | SHARIAT MAMAK | DALILI HOSEIN | KEIHANIDOOST ZARRIN | Issue Writer Certificate

Keywords

URSODEOXYCHOLIC ACID

LIVER TRANSAMINASES

DRUG INDUCED HEPATITIS

ANTICONVULSANT DRUGS

Abstract

The present study has been directed to investigate URSODEOXYCHOLIC ACID (UDCA) effect in children, to reduce the high LIVER TRANSAMINASES induced by ANTICONVULSANT DRUGS (drug induced hepatitis). This idea has been driven from Cytoprotective and antioxidant properties of UDCA to be used in drug induced inflammation in Liver. Twenty two epileptic patients aged between 4mo – 3yr whom were under anticonvulsant therapy with drugs such as valperoic acid, primidone, levetiracetam, Phenobarbital or any combination of them and had shown LIVER TRANSAMINASES rise, after rule out of Viral-Autoimmune, Metabolic and Anatomic causes, have been prescribed UDCA in dose of 10-15 mg/kg/day, at least for 6 months. Any patient who have shown confusing factors such as genetic disorders with liver involvement or spontaneous decline in enzymes or had not treatment compliance has been excluded from the study. Transaminases range changes as well as Probable side effects of the drug have been monitored. The results indicated that UDCA is effective and well tolerable in the children with drug induced hyper transaminasemia. No side effect has been seen and recorded in this study. Based on this study and its results, we recommend UDCA as a safe and effective choice in drug induced hepatotoxicities.

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APA: Copy

ASGARSHIRAZI, MASOUMEH, SHARIAT, MAMAK, DALILI, HOSEIN, & KEIHANIDOOST, ZARRIN. (2015). URSODEOXYCHOLIC ACID CAN IMPROVE LIVER TRANSAMINASE QUANTITIES IN CHILDREN WITH ANTICONVULSANT DRUGS HEPATOTOXICITY: A PILOT STUDY. ACTA MEDICA IRANICA, 53(6), 351-355. SID. https://sid.ir/paper/278683/en

Vancouver: Copy

ASGARSHIRAZI MASOUMEH, SHARIAT MAMAK, DALILI HOSEIN, KEIHANIDOOST ZARRIN. URSODEOXYCHOLIC ACID CAN IMPROVE LIVER TRANSAMINASE QUANTITIES IN CHILDREN WITH ANTICONVULSANT DRUGS HEPATOTOXICITY: A PILOT STUDY. ACTA MEDICA IRANICA[Internet]. 2015;53(6):351-355. Available from: https://sid.ir/paper/278683/en

IEEE: Copy

MASOUMEH ASGARSHIRAZI, MAMAK SHARIAT, HOSEIN DALILI, and ZARRIN KEIHANIDOOST, “URSODEOXYCHOLIC ACID CAN IMPROVE LIVER TRANSAMINASE QUANTITIES IN CHILDREN WITH ANTICONVULSANT DRUGS HEPATOTOXICITY: A PILOT STUDY,” ACTA MEDICA IRANICA, vol. 53, no. 6, pp. 351–355, 2015, [Online]. Available: https://sid.ir/paper/278683/en

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