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Information Journal Paper

Title

PROMINENT COMPLAINT: A GUIDE TO MEDICAL THERAPY OF OVERACTIVE BLADDER SYNDROME IN OLDER WOMEN

Pages

  125-128

Abstract

 To evaluate OVERACTIVE BLADDER (OAB) with detrusor overactivity (DOA) following OXYBUTYNIN or TOLTERODINE treatment in recommended doses at a four-week course. A total of 100 Iranian women 45 years or older with urgency that also showed idiopathic detrusor overactivity (IDO) in the filling phase of their cystometry were included in the current study. In this double-blinded trial two parallel groups were randomized by using two kinds of the antimuscarinic drugs for a four- week course [oxybutinin 5mg, t.d.s. or Tolterodin 2mg, b.i.d.] in the same packages. Data were collected from three-day FREQUENCY VOLUME CHART (FVC) one month before and after the treatment course. The effectiveness of each drug was compared using the paired, samples t-test. Patients’ improvement regarding urinary urgency, frequency and urge incontinence after treatment in both groups was seen, but mean improvements in the terms of urgency and urge incontinence were larger in patients who were treated by OXYBUTYNIN. Night-time frequency was shown to be improved by a significantly larger score by TOLTERODINE. Discontinuation of treatment due to adverse events had no significant difference in two groups. Four-week treatment with OXYBUTYNIN was better than TOLTERODINE IR in improving urgency and urge incontinence, but there were not statistically significant difference between them. In planning a course of treatment especially in the elderly, the difference in the group of symptoms that reduce patients’ quality of life should be considered. Physicians should consider the patient's prominent symptom in selection of anti-muscarinic drugs for the treatment of OVERACTIVE BLADDER syndrome especially in elderly patients.

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    APA: Copy

    JAFARABADI, MINA, GHANBARI, ZINAT, HASHEMI, SHAHRZAD, NEMATI, MARYAM, HAGHOLLAHI, FEDYEH, & AZIMI NEKOO, ELHAM. (2015). PROMINENT COMPLAINT: A GUIDE TO MEDICAL THERAPY OF OVERACTIVE BLADDER SYNDROME IN OLDER WOMEN. ACTA MEDICA IRANICA, 53(2), 125-128. SID. https://sid.ir/paper/278727/en

    Vancouver: Copy

    JAFARABADI MINA, GHANBARI ZINAT, HASHEMI SHAHRZAD, NEMATI MARYAM, HAGHOLLAHI FEDYEH, AZIMI NEKOO ELHAM. PROMINENT COMPLAINT: A GUIDE TO MEDICAL THERAPY OF OVERACTIVE BLADDER SYNDROME IN OLDER WOMEN. ACTA MEDICA IRANICA[Internet]. 2015;53(2):125-128. Available from: https://sid.ir/paper/278727/en

    IEEE: Copy

    MINA JAFARABADI, ZINAT GHANBARI, SHAHRZAD HASHEMI, MARYAM NEMATI, FEDYEH HAGHOLLAHI, and ELHAM AZIMI NEKOO, “PROMINENT COMPLAINT: A GUIDE TO MEDICAL THERAPY OF OVERACTIVE BLADDER SYNDROME IN OLDER WOMEN,” ACTA MEDICA IRANICA, vol. 53, no. 2, pp. 125–128, 2015, [Online]. Available: https://sid.ir/paper/278727/en

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