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Information Journal Paper

Title

DIAGNOSTIC VALUE OF IL-6, CRP, WBC, AND ABSOLUTE NEUTROPHIL COUNT TO PREDICT SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS

Pages

  408-411

Abstract

 Since clinical manifestations of most FEBRILE INFANTS younger than three months old are nonspecific, differentiation of SERIOUS BACTERIAL INFECTION (SBI) from self-limiting viral illness is a significant challenge for pediatricians. This study was performed to assess the diagnostic value of white blood cell count (WBC), Absolute Neutrophil Count (ANC), Interleukin -6 (IL-6) and C-reactive protein (CRP) level to predict SBI in FEBRILE INFANTS younger than three months old who were hospitalized. This was a diagnostic test validation study. In this prospective study, 195 FEBRILE INFANTS admitted to 17 Shahrivar Hospital underwent a full sepsis workup including blood, urine, cerebrospinal fluid cultures and chest radiography. WBC count, ANC and CRP and IL-6 level were measured in all patients. Serum IL-6 concentration was measured by Enzyme-linked Immunosorbent Assay test. Then diagnostic, values of these tests for predicting SBI was compared with each other. Of total cases, 112 (57.4%) infants were male. SBI was diagnosed in 29 (14.9%) patients. The most common type of SBI was Urinary Tract Infection (UTI). Serum IL-6 (³20pg/dl) had sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 79/1%, 91.6%, 75.4%, 60.3%, respectively and for CRP (³10mg/l) values were 81.6%, 89.8%, 78.2%, and 52%, respectively. The predictive values of CRP and IL-6 were higher than WBC and ANC. IL-6 and CRP are more valid and better diagnostic markers for predicting SBI than WBC count and ANC. CRP level seems to be an accessible and cost-effective marker for early diagnosis of SBI. Since by no marker we can totally rule out SBI in FEBRILE INFANTS < three months of age, it is recommended to administer systemic antibiotics until culture results become available.

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    APA: Copy

    ZARKESH, MARJANEH, SEDAGHAT, FATEMEH, HEIDARZADEH, ABTIN, TABRIZI, MANIZHEH, BOLOOKI MOGHADAM, KOBRA, & GHESMATI, SOHEIL. (2015). DIAGNOSTIC VALUE OF IL-6, CRP, WBC, AND ABSOLUTE NEUTROPHIL COUNT TO PREDICT SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS. ACTA MEDICA IRANICA, 53(7), 408-411. SID. https://sid.ir/paper/278770/en

    Vancouver: Copy

    ZARKESH MARJANEH, SEDAGHAT FATEMEH, HEIDARZADEH ABTIN, TABRIZI MANIZHEH, BOLOOKI MOGHADAM KOBRA, GHESMATI SOHEIL. DIAGNOSTIC VALUE OF IL-6, CRP, WBC, AND ABSOLUTE NEUTROPHIL COUNT TO PREDICT SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS. ACTA MEDICA IRANICA[Internet]. 2015;53(7):408-411. Available from: https://sid.ir/paper/278770/en

    IEEE: Copy

    MARJANEH ZARKESH, FATEMEH SEDAGHAT, ABTIN HEIDARZADEH, MANIZHEH TABRIZI, KOBRA BOLOOKI MOGHADAM, and SOHEIL GHESMATI, “DIAGNOSTIC VALUE OF IL-6, CRP, WBC, AND ABSOLUTE NEUTROPHIL COUNT TO PREDICT SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS,” ACTA MEDICA IRANICA, vol. 53, no. 7, pp. 408–411, 2015, [Online]. Available: https://sid.ir/paper/278770/en

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