THE ROLE OF IL-6 FOR PREDICTING NEONATAL SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

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SHAHKAR LOBAT; KESHTKAR ABBASALI; MIRFAZELI AREZOU; AHANI ALI; ROSHANDEL GHOLAMREZA

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Journal: Iranian Journal of Pediatrics Year:2011 | Volume:21 | Issue:4 Page(s): 411-417

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Title

THE ROLE OF IL-6 FOR PREDICTING NEONATAL SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author(s)

Keywords

INTERLUKIN-6

CYTOKINES

SEPSIS

NEONATE

META-ANALYSIS

Abstract

Objective: Neonatal SEPSIS (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS. We conducted this review to assess the validity of IL-6 for predicting NS.Methods: This was a systematic review with META-ANALYSIS. Embase, Medline and Web of Science databases were searched between January 1990 and December 2009. The search terms used were “cytokine”, “neonate”, “sepsis” and“interleukin-6". We used standard methods recommended for meta analyses of diagnostic test evaluations. The analysis was based on a summary ROC (SROC) curve. Meta-regression analysis was used to assess the effects of some confounding factors on the results of META-ANALYSIS. Potential presence of publication bias was tested using funnel plots and the Egger test.Findings: META-ANALYSIS was performed on 13 publications including 353 infants with SEPSIS and 691 control infants. The pooled sensitivity and specificity of IL-6 was 0.79 and 0.84, respectively. The maximum joint sensitivity and specificity (i.e., the Q value) in SROC curve was 0.82 and the area under curve (AUC) was 0.89 (95% CI: 0.84-0.94). Meta-regression analysis showed that the diagnostic accuracy of IL-6 was not affected by confounding variables. The evaluation of publication bias showed that the Egger test was not significant (P=0.07).Conclusion: IL-6 seems to be a valid marker for predicting NS. It may be considered for early diagnosis of SEPSIS in neonatal care units.

Cites

DIAGNOSTIC VALUE OF IL-6, CRP, WBC, AND ABSOLUTE NEUTROPHIL COUNT TO PREDICT SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS

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APA: Copy

SHAHKAR, LOBAT, KESHTKAR, ABBASALI, MIRFAZELI, AREZOU, AHANI, ALI, & ROSHANDEL, GHOLAMREZA. (2011). THE ROLE OF IL-6 FOR PREDICTING NEONATAL SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF PEDIATRICS, 21(4), 411-417. SID. https://sid.ir/paper/589327/en

Vancouver: Copy

SHAHKAR LOBAT, KESHTKAR ABBASALI, MIRFAZELI AREZOU, AHANI ALI, ROSHANDEL GHOLAMREZA. THE ROLE OF IL-6 FOR PREDICTING NEONATAL SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2011;21(4):411-417. Available from: https://sid.ir/paper/589327/en

IEEE: Copy

LOBAT SHAHKAR, ABBASALI KESHTKAR, AREZOU MIRFAZELI, ALI AHANI, and GHOLAMREZA ROSHANDEL, “THE ROLE OF IL-6 FOR PREDICTING NEONATAL SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS,” IRANIAN JOURNAL OF PEDIATRICS, vol. 21, no. 4, pp. 411–417, 2011, [Online]. Available: https://sid.ir/paper/589327/en

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