GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA

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TARIGHI PARASTOO; KHORRAMIZADEH MOHAMMAD REZA; MADADKAR SOBHANI ARMIN; OSTAD SEYED NASSER; GHAHREMANI MOHAMMAD HOSSEIN

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Journal: ACTA MEDICA IRANICA Year:2015 | Volume:53 | Issue:7 Page(s): 403-407

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Title

GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA

Author(s)

Keywords

UPA

UPAR

PEPTIDE

GROWTH INHIBITION

CANCER

Abstract

Interaction between urokinase-type plasminogen activator (UPA) and its receptor (UPAR) plays an important role in the progression of numerous CANCER types including breast CANCER by promoting tumor initiating, proliferation, invasion and metastasis. Hence, disruption of this interaction inhibits their downstream cascades and subsequently tumor growth. For this, we created two series of 8 and 10 amino acids linear PEPTIDEs, derived from UPA binding region to target UPAR and studied the inhibition of proliferation in MDA-MB-231 cell line. Results revealed that all of the 10-mer PEPTIDEs inhibited breast CANCER cell proliferation significantly with maximum 40% inhibition of 103 PEPTIDEs. Meanwhile, none of the 8-mer PEPTIDEs showed significant toxicity. Current results indicate that the linear 10-mer PEPTIDEs which mimic a small part of a sequence of a binding domain of UPA to UPAR could be exploited to design a novel class of anti-cancer agents.

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APA: Copy

TARIGHI, PARASTOO, KHORRAMIZADEH, MOHAMMAD REZA, MADADKAR SOBHANI, ARMIN, OSTAD, SEYED NASSER, & GHAHREMANI, MOHAMMAD HOSSEIN. (2015). GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA. ACTA MEDICA IRANICA, 53(7), 403-407. SID. https://sid.ir/paper/278775/en

Vancouver: Copy

TARIGHI PARASTOO, KHORRAMIZADEH MOHAMMAD REZA, MADADKAR SOBHANI ARMIN, OSTAD SEYED NASSER, GHAHREMANI MOHAMMAD HOSSEIN. GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA. ACTA MEDICA IRANICA[Internet]. 2015;53(7):403-407. Available from: https://sid.ir/paper/278775/en

IEEE: Copy

PARASTOO TARIGHI, MOHAMMAD REZA KHORRAMIZADEH, ARMIN MADADKAR SOBHANI, SEYED NASSER OSTAD, and MOHAMMAD HOSSEIN GHAHREMANI, “GROWTH INHIBITION OF MDA-MB-231 CELL LINE BY PEPTIDES DESIGNED BASED ON UPA,” ACTA MEDICA IRANICA, vol. 53, no. 7, pp. 403–407, 2015, [Online]. Available: https://sid.ir/paper/278775/en

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