Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’ s Disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FAHANIK BABAEI JAVAD; BALUCHNEJADMOJARAD TOURANDOKHT; NIKBAKHT FARNAZ; ROGHANI MEHRDAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ACTA MEDICA IRANICA Year:2018 | Volume:56 | Issue:10 Page(s): 625-634

Download Full-Text

View:

142

Download:

Cites:

Information Journal Paper

Title

Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’ s Disease

Author(s)

FAHANIK BABAEI JAVAD | BALUCHNEJADMOJARAD TOURANDOKHT | NIKBAKHT FARNAZ | ROGHANI MEHRDAD | Issue Writer Certificate

Keywords

Trigonelline

Alzheimer’

s disease

Amyloid β

Learning and memory

Synaptic plasticity

Long-term potentiation

Abstract

Intrahippocampal Amyloid β; (Aβ ) negatively affects Synaptic plasticity with subsequent impairment of Learning and memory. Trigonelline is an alkaloid commonly found in fenugreek seeds and coffee beans with neuroprotective property and a promising agent for management of neurodegenerative disorders like Alzheimer’; s disease (AD). In the present study, the possible beneficial effect of Trigonelline on the improvement of Learning and memory and Synaptic plasticity was evaluated in Aβ (1-40) rat model of AD. For modeling AD, aggregated A𝛽 (1-40) (10 𝜇 g/2 𝜇 l for each side) was bilaterally microinjected into the hippocampal CA1 area. Trigonelline was administered p. o. at a dose of 100 mg/kg. The results showed that Trigonelline pretreatment of Aβ-microinjected rats ameliorates Learning and memory deficit in passive avoidance task and spatial memory impairment in Morris water maze (MWM) paradigm. It also improved population spike (PS) amplitude and field excitatory post-synaptic potential (fEPSP) slope following application of high frequency stimulation (HFS) to induce Long-term potentiation (LTP) in medial perforant-dentate gyrus pathway as an index of Synaptic plasticity. Additionally, Trigonelline mitigated hippocampal activity of acetylcholinesterase (AChE). In summary, Trigonelline pretreatment of intrahippocampal Aβ-microinjected rats could ameliorate Learning and memory impairment, partly through restoring hippocampal Synaptic plasticity and AChE and it may be suggested as an adjunct and promising oral bioactive therapeutic agent that may prevent memory deterioration in AD.

Cites

No record.

References

No record.

Cite

APA: Copy

FAHANIK BABAEI, JAVAD, BALUCHNEJADMOJARAD, TOURANDOKHT, NIKBAKHT, FARNAZ, & ROGHANI, MEHRDAD. (2018). Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’ s Disease. ACTA MEDICA IRANICA, 56(10), 625-634. SID. https://sid.ir/paper/279036/en

Vancouver: Copy

FAHANIK BABAEI JAVAD, BALUCHNEJADMOJARAD TOURANDOKHT, NIKBAKHT FARNAZ, ROGHANI MEHRDAD. Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’ s Disease. ACTA MEDICA IRANICA[Internet]. 2018;56(10):625-634. Available from: https://sid.ir/paper/279036/en

IEEE: Copy

JAVAD FAHANIK BABAEI, TOURANDOKHT BALUCHNEJADMOJARAD, FARNAZ NIKBAKHT, and MEHRDAD ROGHANI, “Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’ s Disease,” ACTA MEDICA IRANICA, vol. 56, no. 10, pp. 625–634, 2018, [Online]. Available: https://sid.ir/paper/279036/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops