IMMUNOLOGICAL CHANGES IN HYPOTHYROID WOMEN

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JAFARZADEH A.; SAJADI S.M.A.

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Paper Information

Journal: Iranian Journal of Endocrinology & Metabolism Year:2004 | Volume:5 | Issue:4 (SN 20) Page(s): 249-254

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Information Journal Paper

Title

IMMUNOLOGICAL CHANGES IN HYPOTHYROID WOMEN

Author(s)

JAFARZADEH A. | SAJADI S.M.A. | Issue Writer Certificate

Keywords

HYPOTHYROIDISMQ4

IMMUNOGLOBULINSQ4

COMPLEMENTQ4

WHITE BLOOD CELL COUNTQ4

WOMENQ2

Abstract

Introduction: There is considerable experimental evidence for effects of thyroid hormones on immune system. An association between HYPOTHYROIDISM and susceptibility to some infections has been also demonstrated. The aim of this study was to evaluate immunological changes in hypothyroid females. Materials and Methods: Blood samples were collected from 50 females with HYPOTHYROIDISM and a control group consisting of 50 sex- and age-matched euthyroid subjects. Thyroid function was assessed according to T3, T4 and TSH levels. The following parameters were studied in the two groups: total and differential white blood cell (WBC) counts, serum concentration of IMMUNOGLOBULINS including IgG, IgA, IgM and IgE, CRP, C3 and C4 COMPLEMENT components. Results: Decreased serum concentration of IgG and IgA was observed in hypothyroid patients compared to euthyroid females. Hypothyroid females had higher serum IgE concentration than euthyroid group (179.8 IU/ml vs. 109.8 IU/ml; P<0.05). Similarly serum C3 concentration in hypothyroid patients was significantly higher as compared to euthyroid females (138.8 mg/ml vs. 117.8 mg/dl; P<0.01). In euthyroid group the absolute count of circulating WBC, PMN cells and lymphocytes were slightly higher than those in hypothroid group. On the other hand, the eosinophil count was higher in hypothyroid patients as compared to control group. Conclusion: These results indicate that some immunological alterations occur in hypothyroid WOMEN

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APA: Copy

JAFARZADEH, A., & SAJADI, S.M.A.. (2004). IMMUNOLOGICAL CHANGES IN HYPOTHYROID WOMEN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 5(4 (SN 20)), 249-254. SID. https://sid.ir/paper/27908/en

Vancouver: Copy

JAFARZADEH A., SAJADI S.M.A.. IMMUNOLOGICAL CHANGES IN HYPOTHYROID WOMEN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2004;5(4 (SN 20)):249-254. Available from: https://sid.ir/paper/27908/en

IEEE: Copy

A. JAFARZADEH, and S.M.A. SAJADI, “IMMUNOLOGICAL CHANGES IN HYPOTHYROID WOMEN,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 5, no. 4 (SN 20), pp. 249–254, 2004, [Online]. Available: https://sid.ir/paper/27908/en

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