The Outbreak of Lead Poisoning in Opium Users: Presentation and Chelation Therapy

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Aghabiklooei Abbas; Saburi Hanieh; Soleymanzadeh Hosnieh; AMERI MARYAM

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2018 | Volume:56 | Issue:11 Page(s): 710-715

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Information Journal Paper

Title

The Outbreak of Lead Poisoning in Opium Users: Presentation and Chelation Therapy

Author(s)

Aghabiklooei Abbas | Saburi Hanieh | Soleymanzadeh Hosnieh | AMERI MARYAM | Issue Writer Certificate

Keywords

Opium

Lead

Poisoning

Chelator

Therapy

Abstract

Recently, there have been a few reports of an outbreak of Lead Poisoning due to Opium contaminated with Lead in Iran. This study aimed to evaluate the clinical features of Lead toxicity in Opium abusers, and response to oral chelation Therapy based on the severity of Poisoning. One hundred thirty-three chronic Opium users with a diagnosis of Lead Poisoning were included. Based on blood Lead level (BLL), the cases were divided into 2 mild (BLL; 40-69 μ g/dL) and moderate (BLL; 70-100) groups. Both groups received D-penicillamine (D-P) as a Chelator. Changes in BLL compared between two groups. All cases were oral Opium users. Abdominal pain (75%), anorexia (55. 6%), and constipation (53. 2%) were the most common symptoms of Lead Poisoning. 67. 8% of cases experienced only one round of chelation Therapy and "Rebound phenomenon" happened in 9% of these. Ninety percent of the patients had wellbeing sensation, and symptoms improved at the end of the first round of treatment. The mean BLL before and after chelation Therapy were 66. 87 and 45. 7 μ g/dL, respectively. Oral Chelator reduced BLL in both mild and moderate Poisoning groups (35. 61% vs. 35. 90%, P: 0. 057), respectively. The comparison of BLL before and after chelation Therapy showed that the treatment was effective equally in both mild and moderate toxicity. However, in a few cases, the rebound phenomenon may occur.

Cites

Lead Contamination in Opium, Opium Tincture, and Methadone Oral Solution, in Iran

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APA: Copy

Aghabiklooei, Abbas, Saburi, Hanieh, Soleymanzadeh, Hosnieh, & AMERI, MARYAM. (2018). The Outbreak of Lead Poisoning in Opium Users: Presentation and Chelation Therapy. ACTA MEDICA IRANICA, 56(11), 710-715. SID. https://sid.ir/paper/279084/en

Vancouver: Copy

Aghabiklooei Abbas, Saburi Hanieh, Soleymanzadeh Hosnieh, AMERI MARYAM. The Outbreak of Lead Poisoning in Opium Users: Presentation and Chelation Therapy. ACTA MEDICA IRANICA[Internet]. 2018;56(11):710-715. Available from: https://sid.ir/paper/279084/en

IEEE: Copy

Abbas Aghabiklooei, Hanieh Saburi, Hosnieh Soleymanzadeh, and MARYAM AMERI, “The Outbreak of Lead Poisoning in Opium Users: Presentation and Chelation Therapy,” ACTA MEDICA IRANICA, vol. 56, no. 11, pp. 710–715, 2018, [Online]. Available: https://sid.ir/paper/279084/en

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