IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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Imani Danyal; REZAEI RAMAZAN; JAFARI DAVOOD; Razi Bahman; alizadeh shahab; BASHASHATI MOHAMMAD; REZAEI NIMA

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Journal: ACTA MEDICA IRANICA Year:2018 | Volume:56 | Issue:12 Page(s): 740-749

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Title

IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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Keywords

Interleukin-6

Polymorphism

Inflammatory bowel disease

Meta-analysis

Abstract

The results of previous studies on the association between IL-6-174G/C (rs1800795) Polymorphism and Inflammatory bowel disease (IBD), including Crohn’ s disease (CD) and ulcerative colitis (UC) are not consistent. The present Meta-analysis has pooled all eligible studies to understand the relation between this gene Polymorphism and IBD risk. A structured search of Medline, EMBASE, and Scopus databases were performed to identify all eligible studies published before June 2017. Odds ratio (OR) and 95% confidence intervals (CIs) were assessed applying fixed-or random-effect models to evaluate the strength of association in recessive model, dominant model, allelic model, heterozygote contrast, and homozygotes contrast. A sum of 9 articles with 1524 IBD cases and 1586 healthy subjects were included in this study. No significant association between the IL-6-174 G/C Polymorphism and overall IBD susceptibility in any tested genetic model was found. Moreover, in the subgroup analysis based on subtypes, the associations between the IL-6 174-G/C Polymorphism and CD and UC missed statistical significance. The current Meta-analysis suggests that the IL-6-174 G/C Polymorphism is not associated with IBD susceptibility. Further and comprehensive studies are necessary to warrant this result.

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APA: Copy

Imani, Danyal, REZAEI, RAMAZAN, JAFARI, DAVOOD, Razi, Bahman, alizadeh, shahab, BASHASHATI, MOHAMMAD, & REZAEI, NIMA. (2018). IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. ACTA MEDICA IRANICA, 56(12), 740-749. SID. https://sid.ir/paper/279119/en

Vancouver: Copy

Imani Danyal, REZAEI RAMAZAN, JAFARI DAVOOD, Razi Bahman, alizadeh shahab, BASHASHATI MOHAMMAD, REZAEI NIMA. IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. ACTA MEDICA IRANICA[Internet]. 2018;56(12):740-749. Available from: https://sid.ir/paper/279119/en

IEEE: Copy

Danyal Imani, RAMAZAN REZAEI, DAVOOD JAFARI, Bahman Razi, shahab alizadeh, MOHAMMAD BASHASHATI, and NIMA REZAEI, “IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis,” ACTA MEDICA IRANICA, vol. 56, no. 12, pp. 740–749, 2018, [Online]. Available: https://sid.ir/paper/279119/en

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