Evaluation of Topiramate Efficacy on Neuropathic Pain in Patients With Diabetic Polyneuropathy

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Shamsinejad Sedigheh; DAVATI ALI; Roughani Mehrdad; Ghasemlouie Amir; AFSHINMAJD SIAMAK

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ACTA MEDICA IRANICA Year:2018 | Volume:56 | Issue:12 Page(s): 764-768

Download Full-Text

View:

152

Download:

192

Cites:

Information Journal Paper

Title

Evaluation of Topiramate Efficacy on Neuropathic Pain in Patients With Diabetic Polyneuropathy

Author(s)

Keywords

Topiramate

Gabapentin

Pain

Diabetes

Polyneuropathy

Abstract

Polyneuropathy is one of the most common and disabling complications of Diabetes. Severe Pain is one of the complications of diabetic Polyneuropathy. Over the years, many drugs for the treatment of the Pain in diabetic neuropathy have been tried. However, no one is completely effective. In a single-blind clinical trial, 200 patients with Painful diabetic neuropathy were studied over 12 weeks. In the intervention group, 100 patients were treated with 100 milligrams of Topiramate per day and 100 patients in the control group treated with 90 milligrams of Gabapentin per day. Pain intensity recorded with Visual analogue scale between 0 to 100 millimeter over twelve weeks. Reduction in Pain intensity of ≥ 30 mm was considered as effective response. The purpose of this study was to investigate the effect of Topiramate in the treatment of Pain in diabetic Polyneuropathy. The mean reduction in Pain intensity over twelve weeks in Topiramate groups were 33. 83± 12. 17 and in Gabapentin group were 30. 25± 15. 66. The relative improvement in the Topiramate group was 89. 17%, and in the Gabapentin group was 71. 25%, respectively. There was a reduction in the mean Pain score in both groups, although no statistically significant difference between the two groups was observed. Both of Topiramate and Gabapentin were effective on reduction of Pain in diabetic Polyneuropathy. We can use both of them separately or in combination with each other or other drugs.

Cites

No record.

References

No record.

Cite

APA: Copy

Shamsinejad, Sedigheh, DAVATI, ALI, Roughani, Mehrdad, Ghasemlouie, Amir, & AFSHINMAJD, SIAMAK. (2018). Evaluation of Topiramate Efficacy on Neuropathic Pain in Patients With Diabetic Polyneuropathy. ACTA MEDICA IRANICA, 56(12), 764-768. SID. https://sid.ir/paper/279121/en

Vancouver: Copy

Shamsinejad Sedigheh, DAVATI ALI, Roughani Mehrdad, Ghasemlouie Amir, AFSHINMAJD SIAMAK. Evaluation of Topiramate Efficacy on Neuropathic Pain in Patients With Diabetic Polyneuropathy. ACTA MEDICA IRANICA[Internet]. 2018;56(12):764-768. Available from: https://sid.ir/paper/279121/en

IEEE: Copy

Sedigheh Shamsinejad, ALI DAVATI, Mehrdad Roughani, Amir Ghasemlouie, and SIAMAK AFSHINMAJD, “Evaluation of Topiramate Efficacy on Neuropathic Pain in Patients With Diabetic Polyneuropathy,” ACTA MEDICA IRANICA, vol. 56, no. 12, pp. 764–768, 2018, [Online]. Available: https://sid.ir/paper/279121/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops