EFFECTS OF IRON SUPPLEMENTATION WITH OR WITHOUT VITAMIN C ON OXIDATIVE STRESS AND IRON STATUS IN IRON DEFICIENT FEMALE COLLEGE STUDENTS

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KHOUSH FETRAT M.R.; KALANTARI NASER; MOHAMMADI NASRABADI F.; RASHIDI ARASH; REZA NEYESTANI TIRANG; ABADI ALI REZA; ESMAEILZADEH AHMAD

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2008 | Volume:10 | Issue:1 (SN 37) Page(s): 25-33

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Title

EFFECTS OF IRON SUPPLEMENTATION WITH OR WITHOUT VITAMIN C ON OXIDATIVE STRESS AND IRON STATUS IN IRON DEFICIENT FEMALE COLLEGE STUDENTS

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Keywords

IRON DEFICIENCYQ3

VITAMIN CQ3

OXIDATIVE STRESSQ2

TOTAL ANTIOXIDANT CAPACITYQ2

MALONDIALDEHYDEQ2

IRON SUPPLEMENTATIONQ3

Abstract

Introduction: Iron excess disturbs the antioxidant system through pro-oxidants mechanisms. In this study, OXIDATIVE STRESS indices were compared between iron deficient and healthy subjects and effects of IRON SUPPLEMENTATION with and/or without ascorbic acid on performance of the antioxidant defense system, levels of OXIDATIVE STRESS and iron status in iron deficient female students were determined. Materials and Methods: In this double-blind randomized clinical trial, 60 NAID and 30 normal students (control) were selected from 289 female students at the dormitory of Shaheed Beheshti University (MC), Tehran. Hemoglobin and serum ferritin concentrations were measured by cell counter and ELISA, respectively. After matching, NAIDM students were randomly assigned into the intervention group receiving 50 mg/d elemental iron supplements without (group I) and/or with (group II) 500 mg/d ascorbic acid for 12 weeks. Serum MALONDIALDEHYDE (MDA), TOTAL ANTIOXIDANT CAPACITY (TAC) and serum ascorbic acid were measured at the beginning and the end of the 6th and 12th weeks in the groups studied. Student's t and repeated measurements tests were employed to analyze the data using SPSS software. Results: Mean TAC in group III was significantly higher in NAID subjects at the beginning of the study (3.87±0.47 vs 3.4±0.41 mmol/mL; p<0.001). At the end, serum TAC significantly increased in supplemented subjects, not only compared to the baseline values (within group), but also in comparison with controls (between groups) (5.1±.3 vs 4.7±0.04 mmol/mL; p<0.001). In contrast, serum MDA concentrations decreased from 1.7±0.14 to 1.1±0.09 nmol/mL (p<0.001) and from 1.9±0.18 to 1.7±0.15 nmol/mL (p<0.001) in groups I and II, respectively, after 6 weeks of supplementation. Serum MDA concentration however increased to 1.7±0.15 nmol/mL at the 12th week (p<0.001); although the same results were seen in group II, but the mean MDA concentration was significantly less than the value at the beginning (1.4±0.1 vs 1.9±0.18 nmol/mL; p<0.03). Conclusion: It seems that the status of the anti-oxidant defense systems significantly improves among NAID young female subjects within the first few weeks after IRON SUPPLEMENTATION especially with ascorbic acid, an approach recommended for more efficient control of IRON DEFICIENCY.

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APA: Copy

KHOUSH FETRAT, M.R., KALANTARI, NASER, MOHAMMADI NASRABADI, F., RASHIDI, ARASH, REZA NEYESTANI, TIRANG, ABADI, ALI REZA, & ESMAEILZADEH, AHMAD. (2008). EFFECTS OF IRON SUPPLEMENTATION WITH OR WITHOUT VITAMIN C ON OXIDATIVE STRESS AND IRON STATUS IN IRON DEFICIENT FEMALE COLLEGE STUDENTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(1 (SN 37)), 25-33. SID. https://sid.ir/paper/27921/en

Vancouver: Copy

KHOUSH FETRAT M.R., KALANTARI NASER, MOHAMMADI NASRABADI F., RASHIDI ARASH, REZA NEYESTANI TIRANG, ABADI ALI REZA, ESMAEILZADEH AHMAD. EFFECTS OF IRON SUPPLEMENTATION WITH OR WITHOUT VITAMIN C ON OXIDATIVE STRESS AND IRON STATUS IN IRON DEFICIENT FEMALE COLLEGE STUDENTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;10(1 (SN 37)):25-33. Available from: https://sid.ir/paper/27921/en

IEEE: Copy

M.R. KHOUSH FETRAT, NASER KALANTARI, F. MOHAMMADI NASRABADI, ARASH RASHIDI, TIRANG REZA NEYESTANI, ALI REZA ABADI, and AHMAD ESMAEILZADEH, “EFFECTS OF IRON SUPPLEMENTATION WITH OR WITHOUT VITAMIN C ON OXIDATIVE STRESS AND IRON STATUS IN IRON DEFICIENT FEMALE COLLEGE STUDENTS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 1 (SN 37), pp. 25–33, 2008, [Online]. Available: https://sid.ir/paper/27921/en

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