EFFECT OF VITAMIN A-ZINC SUPPLEMENTATION ON OXIDATIVE STRESS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS

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OSTAD RAHIMI A.R.; SEYEDREZAZADEH E.; MAHBOUB S.; DAST GIRI S.; ASSADI Y.; HABIBZADEH D.; GAEM MAGHAMI J.; POURMOGHADAM M.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2006 | Volume:28 | Issue:3 Page(s): 11-15

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Title

EFFECT OF VITAMIN A-ZINC SUPPLEMENTATION ON OXIDATIVE STRESS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS

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Keywords

TUBERCULOSISQ2

VITAMIN AQ2

ZINCQ3

OXIDATIVE STRESSQ3

Abstract

Background and Objectives: TUBERCULOSIS (TB) is a chronic infectious and one of the ancient disease that has long been a major public health challenge in the world. WHO declared TB as a global health emergency. On the other hand some micronutrient with antioxidant and immunomodulator properties have vital role to decrease OXIDATIVE STRESS and regulation of immune homeostasis. Therefore the aimed this study was to determine the effects of VITAMIN Azinc supplementation on OXIDATIVE STRESS status in patient with active pulmonary TUBERCULOSIS.Material and Method: Research was designed as a double-blind placebo controlled trial on thirty-five newly diagnosed active pulmonary TB outpatients from TUBERCULOSIS & Lung Diseases Research Center of Tabriz. Patients were assigned into 2 groups; one group received anti-TB drugs and VITAMIN A - ZINC supplementation (vitamin A: 1500μgRE and ZINC: 15mg) and the other group received the anti-TB drugs and placebo. Five ml venus blood was obtained from all subjects at the beginning and 2 months after intervention. Weight and height were measured and BMI was calculated. Plasma level of VITAMIN A and total antioxidant was determined by using HPLC and kit methods respectively, Serum malondialdehyde was measured based on thiobarbituric acid reaction florimetry method, and ZINC by flame atomic absorption.Results: serum MDA reduced and plasma total antioxidant elevated significantly in VITAMIN A- ZINC supplemented and control patients (P<0.001), but there was no significant difference between case and control group.Conclusion: Anti-TB treatments reduce Serum malondialdehyde level, elevate plasma total antioxidant and decrease stress oxidative in patient with TUBERCULOSIS.

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APA: Copy

OSTAD RAHIMI, A.R., SEYEDREZAZADEH, E., MAHBOUB, S., DAST GIRI, S., ASSADI, Y., HABIBZADEH, D., GAEM MAGHAMI, J., & POURMOGHADAM, M.. (2006). EFFECT OF VITAMIN A-ZINC SUPPLEMENTATION ON OXIDATIVE STRESS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 28(3), 11-15. SID. https://sid.ir/paper/47360/en

Vancouver: Copy

OSTAD RAHIMI A.R., SEYEDREZAZADEH E., MAHBOUB S., DAST GIRI S., ASSADI Y., HABIBZADEH D., GAEM MAGHAMI J., POURMOGHADAM M.. EFFECT OF VITAMIN A-ZINC SUPPLEMENTATION ON OXIDATIVE STRESS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;28(3):11-15. Available from: https://sid.ir/paper/47360/en

IEEE: Copy

A.R. OSTAD RAHIMI, E. SEYEDREZAZADEH, S. MAHBOUB, S. DAST GIRI, Y. ASSADI, D. HABIBZADEH, J. GAEM MAGHAMI, and M. POURMOGHADAM, “EFFECT OF VITAMIN A-ZINC SUPPLEMENTATION ON OXIDATIVE STRESS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3, pp. 11–15, 2006, [Online]. Available: https://sid.ir/paper/47360/en

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