WHICH ANESTHETIC DRUG REGIMEN IS SUITABLE FOR CABG SURGERY: PROPOFOL - ATRACURIUM OR PROPOFOL - PANCURONIUM?

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AGHDAMI N.; FARASTAKISH R.; AZAR FARIN R.; MOLA SADEGHI ROKABADI GH.A.

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Journal: Iranian Heart Journal Year:2003 | Volume:4 | Issue:3 Page(s): 25-28

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Title

WHICH ANESTHETIC DRUG REGIMEN IS SUITABLE FOR CABG SURGERY: PROPOFOL - ATRACURIUM OR PROPOFOL - PANCURONIUM?

Author(s)

AGHDAMI N. | FARASTAKISH R. | AZAR FARIN R. | MOLA SADEGHI ROKABADI GH.A.

Keywords

PANCURONIUM M ATRACURIUM M PROPOFOL M HEMODYNAMICS

Abstract

Background- Hemodynamic instability during anesthesia can affect circulation and ‎oxygenation of vital organs (e.g. brain, heart, kidney and liver). Each of the anesthetic ‎drugs has various hemodynamic effects, and the interaction of these drugs may cause ‎critical changes in‏ ‏patients hemodynamics‏.‏‎‎
Propofol is the most recent intravenous anesthetic to be introduced into clinical ‎practice. This drug has negative inotropic effects on the heart. Based on the ‎cardiovascular effects of propofol and to maintain hemodynamic stability during ‎anesthesia with this drug, it seems that selection of a muscle relaxant with positive ‎effects on the heart rate and especially blood pressure, such as pancuronium, is better ‎than atracurium. Therefore, we performed a study of the effects of pancuronium and ‎atracurium on hemodynamic parameters of patients undergoing CABG surgery, in ‎which these muscle relaxants are used in conjunction with propofol-sufentanil‏.‏‎ ‎
Methods- A prospective randomized clinical trial analysis was performed on 100 ‎patients undergoing coronary artery bypass graft surgery in Shaheed Rajaei Heart ‎Center. Fifty of the patients received propofol -pancuronium and 50 of them received ‎propofol - atracurium. The selection of type and dose of premedication drugs and ‎intraoperative opioid use in the two groups was the same. Maintenance of anesthesia ‎in the two groups was achieved by the infusion of specific doses of these drugs‏.‏‎ ‎
Results- Hemodynamic changes in the two groups were almost the same. There was ‎no statistically significant difference (p>0.05) in the two groups (Iranian Heart ‎Journal 2002, 2003; 3(4)&4(1): 25-28).‎

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APA: Copy

AGHDAMI, N., FARASTAKISH, R., AZAR FARIN, R., & MOLA SADEGHI ROKABADI, GH.A.. (2003). WHICH ANESTHETIC DRUG REGIMEN IS SUITABLE FOR CABG SURGERY: PROPOFOL - ATRACURIUM OR PROPOFOL - PANCURONIUM?. IRANIAN HEART JOURNAL (IHJ), 4(3), 25-28. SID. https://sid.ir/paper/279308/en

Vancouver: Copy

AGHDAMI N., FARASTAKISH R., AZAR FARIN R., MOLA SADEGHI ROKABADI GH.A.. WHICH ANESTHETIC DRUG REGIMEN IS SUITABLE FOR CABG SURGERY: PROPOFOL - ATRACURIUM OR PROPOFOL - PANCURONIUM?. IRANIAN HEART JOURNAL (IHJ)[Internet]. 2003;4(3):25-28. Available from: https://sid.ir/paper/279308/en

IEEE: Copy

N. AGHDAMI, R. FARASTAKISH, R. AZAR FARIN, and GH.A. MOLA SADEGHI ROKABADI, “WHICH ANESTHETIC DRUG REGIMEN IS SUITABLE FOR CABG SURGERY: PROPOFOL - ATRACURIUM OR PROPOFOL - PANCURONIUM?,” IRANIAN HEART JOURNAL (IHJ), vol. 4, no. 3, pp. 25–28, 2003, [Online]. Available: https://sid.ir/paper/279308/en

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