مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

466
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

219
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ROLE OF CYTOSKELETAL STRUCTURE IN MODULATION OF INTESTINAL PERMEABILITY

Pages

  49-53

Abstract

 The intestine contains the largest interface between man and his environment; thus, ‎the intestinal barrier could be a key factor in health and disease states. This barrier is a ‎highly selective gatekeeper that permits the passage of nutrients and prevents the ‎penetration of harmful bacterial products and dietary antigens. The intestinal barrier is ‎composed of immunological and non immunological compartments and the latter part ‎is made up of multilayered structural and functional components. The intestinal ‎epithelium and its paracellular tight junctions appear to be the key for integrity of this ‎barrier. The cytoskeletal assembly is essential for maintaining epithelial structure, ‎transport, and functional integrity, but is also pivotal for integrity of the paracellular ‎pathway, especially the tight junction complex. ACTIN and microtubules are two ‎cytoskeletal filaments that play key roles in regulation and maintenance of the ‎intestinal barrier. Various noxious agents such as ethanol and/or oxidants can induce ‎cytoskeletal damage and disruption of barrier integrity. The injurious effects of these ‎compounds are mediated through upregulation and activation of inducible nitric oxide ‎synthase (iNOS) and the resultant NO overproduction and nitration and oxidation of ‎ACTIN and TUBULIN. Oxidized cytoskeletal proteins result in deploymerization of ‎cytoskeletal filaments, cytoskeletal disassembly and disarray and eventually ‎disruption of barrier function. The disrupted barrier can initiate or perpetuate an ‎inflammatory cascade that will result in intestinal mucosal injury and inflammatory ‎bowel disease flare-up. There are several lines of repair/defense that help to brake this ‎inflammatory cascade, reestablish barrier integrity and thus limit or terminate mucosal ‎injury. One of these lines of defense is mediated through protecting factors such as ‎epidermal growth factor, which prevents ethanol-induced and oxidative damage to the ‎gastrointestinal epithelium‏.‏

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    FARHADI, ASHKAN, BANAN, A., & KESHAVARZIAN, A.. (2003). ROLE OF CYTOSKELETAL STRUCTURE IN MODULATION OF INTESTINAL PERMEABILITY . ARCHIVES OF IRANIAN MEDICINE, 6(1), 49-53. SID. https://sid.ir/paper/279818/en

    Vancouver: Copy

    FARHADI ASHKAN, BANAN A., KESHAVARZIAN A.. ROLE OF CYTOSKELETAL STRUCTURE IN MODULATION OF INTESTINAL PERMEABILITY . ARCHIVES OF IRANIAN MEDICINE[Internet]. 2003;6(1):49-53. Available from: https://sid.ir/paper/279818/en

    IEEE: Copy

    ASHKAN FARHADI, A. BANAN, and A. KESHAVARZIAN, “ROLE OF CYTOSKELETAL STRUCTURE IN MODULATION OF INTESTINAL PERMEABILITY ,” ARCHIVES OF IRANIAN MEDICINE, vol. 6, no. 1, pp. 49–53, 2003, [Online]. Available: https://sid.ir/paper/279818/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button