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Title

ALL-TRANS RETINOIC ACID AND INTENSIVE CHEMOTHERAPY IN ACUTE PROMYELOCYTIC LEUKEMIA

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Abstract

 Background-All-Trans Retinoic Acid (ATRA) is a subgroup of the retinoid family, which induces a complete remission in acute promyelocytic leukemia (APL). It causes differentiation and apoptosis in immature malignant promyelocytes. It is not clear whether induction therapy with ATRA followed by intensive chemotherapy is superior to chemotherapy alone in the outcome of these patients. Objective-To investigate the results of treatment with ATRA and intensive chemotherapy in acute promyelocytic leukemia (APL). Methods-A total of thirty patients were enrolled into the study and were treated with ATRA in a prospective study at Shariati Hospital from 1996-99. ATRA was prescribed with a daily dose of 45 mg/m2. In case of ATRA-induced maturation or hyperleukocytosis, intensive chemotherapy was given with cytarabine and idarubicin. This was followed by two additional courses of the same chemotherapy as consolidation. ATRA syndrome was treated with dexamethasone. Results-At the time of diagnosis, clinical and subclinical coagulopathy and all-trans-retinoic acid induced maturation was seen in 96% and 73.3% of patients, respectively. In 26.7% of patients, the response was partial or inconspicuous. All clinical and laboratory evidence of coagulopathy was corrected during the ATRA therapy. ATRA syndrome occurred in 11(42.3%) patients. With a median follow-up period of 1.5 years, 65.4% of patients showed complete remission. Conclusion-This study shows that ATRA is a safe and appropriate treatment for APL, which improves disease-free states and overall survival as compared with chemotherapy alone. We recommend the use of all-trans retinoic acid for induction therapy followed by intensive chemotherapy in patients with APL

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    APA: Copy

    GHAVAMZADEH, ARDESHIR, JAHANI, M., IRAVANI, M., MORTAZAVIZADEH, M.R., RASTGARPANAH, M., BAYBORDI, E., KHODABANDEH, A., & SHAHRIARI, A.. (2000). ALL-TRANS RETINOIC ACID AND INTENSIVE CHEMOTHERAPY IN ACUTE PROMYELOCYTIC LEUKEMIA . ARCHIVES OF IRANIAN MEDICINE, 3(4), 0-0. SID. https://sid.ir/paper/280016/en

    Vancouver: Copy

    GHAVAMZADEH ARDESHIR, JAHANI M., IRAVANI M., MORTAZAVIZADEH M.R., RASTGARPANAH M., BAYBORDI E., KHODABANDEH A., SHAHRIARI A.. ALL-TRANS RETINOIC ACID AND INTENSIVE CHEMOTHERAPY IN ACUTE PROMYELOCYTIC LEUKEMIA . ARCHIVES OF IRANIAN MEDICINE[Internet]. 2000;3(4):0-0. Available from: https://sid.ir/paper/280016/en

    IEEE: Copy

    ARDESHIR GHAVAMZADEH, M. JAHANI, M. IRAVANI, M.R. MORTAZAVIZADEH, M. RASTGARPANAH, E. BAYBORDI, A. KHODABANDEH, and A. SHAHRIARI, “ALL-TRANS RETINOIC ACID AND INTENSIVE CHEMOTHERAPY IN ACUTE PROMYELOCYTIC LEUKEMIA ,” ARCHIVES OF IRANIAN MEDICINE, vol. 3, no. 4, pp. 0–0, 2000, [Online]. Available: https://sid.ir/paper/280016/en

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