COMPARATIVE EFFICACY OF EVERY 2 WEEKS VERSUS EVERY 6 WEEKS INJECTIONS OF FLUPHENAZINE DECANOATE

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KHAZAEI HABIB ELAH; SHAKERI J.

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Journal Paper

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2005 | Volume:8 | Issue:2 Page(s): 109-114

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Title

COMPARATIVE EFFICACY OF EVERY 2 WEEKS VERSUS EVERY 6 WEEKS INJECTIONS OF FLUPHENAZINE DECANOATE

Author(s)

KHAZAEI HABIB ELAH | SHAKERI J. | Issue Writer Certificate

Keywords

FLUPHENAZINE DECANOATE • SCHIZOAFFECTIVE • SCHIZOPHRENIA

Abstract

Background: Maintenance treatment of schizophrenia reduces relapse rates of this disease.
This treatment is carried out for long periods of time and occasionally for lifelong. Dose reduction
strategies are designed to maintain the benefits of antipsychotic drug therapy, while reducing the
side effects. The authors tested a new dose reduction approach by increasing the interval between
administration of intramuscular (IM) injections of fluphenazine decanoate.
Methods: Fifty outpatients with schizophrenia or schizoaffective disorder were randomly
assigned to receive 25mg of fluphenazine decanoate intramuscularly, either every 2 weeks or every
6 weeks, for 54 weeks in a double-blind design.
Results: The two-dose regimens did not differ significantly in the number of relapses or
returning of symptoms, but the 1-year extrapyramidal symptom and dyskinesia scores, adjusted
for baseline, were higher for the “every 2 weeks” than the “every 6 weeks” group.
Conclusion: The use of injections of fluphenazine, every 6 weeks instead of every 2 weeks,
may increase compliance and improve patient’s comfort as well as decreasing cumulative
antipsychotic exposure, without increasing relapse rates or symptoms.

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APA: Copy

KHAZAEI, HABIB ELAH, & SHAKERI, J.. (2005). COMPARATIVE EFFICACY OF EVERY 2 WEEKS VERSUS EVERY 6 WEEKS INJECTIONS OF FLUPHENAZINE DECANOATE. ARCHIVES OF IRANIAN MEDICINE, 8(2), 109-114. SID. https://sid.ir/paper/280036/en

Vancouver: Copy

KHAZAEI HABIB ELAH, SHAKERI J.. COMPARATIVE EFFICACY OF EVERY 2 WEEKS VERSUS EVERY 6 WEEKS INJECTIONS OF FLUPHENAZINE DECANOATE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2005;8(2):109-114. Available from: https://sid.ir/paper/280036/en

IEEE: Copy

HABIB ELAH KHAZAEI, and J. SHAKERI, “COMPARATIVE EFFICACY OF EVERY 2 WEEKS VERSUS EVERY 6 WEEKS INJECTIONS OF FLUPHENAZINE DECANOATE,” ARCHIVES OF IRANIAN MEDICINE, vol. 8, no. 2, pp. 109–114, 2005, [Online]. Available: https://sid.ir/paper/280036/en

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