مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CURRENT TREATMENT OF CHRONIC HEPATITIS B

Pages

  1-10

Abstract

 The primary goal of therapy in patients with chronic hepatitis B is suppression and long-lasting maintenance of hepatitis B virus DNA to its lowest possible level. The threshold of hepatitis B virus DNA level for therapy is ≥.105 copies/mL for HBeAg-positive patients and ≥.104 for those with HBeAg-negative chronic hepatitis B. Interferon alpha-2b, lamivudine, and adefovir-dipivoxil are approved by FDA and could all be used as an initial first-line therapy in chronic hepatitis B. Adding lamivudine to either conventional interferon or peg-interferon did not increase the efficacy. Adding lamivudine to adefovir had also no additional effect in compensated patients. Response rate is about 30% . 40% with first-line drugs. Peg-interferon, which recently received the FDA approval, is associated with an increased response rate. Further long-term studies are required to use peg-interferon as a widespread first-line treatment. Treatment strategy is changing towards using prolonged combination therapy with evolving nucleoside analogues with or without an immunomodulatory agent, aiming at eradicating covalently closed circular DNA.

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    • Cite

    APA: Copy

    MONTAZERI, GH.. (2006). CURRENT TREATMENT OF CHRONIC HEPATITIS B . ARCHIVES OF IRANIAN MEDICINE, 9(1), 1-10. SID. https://sid.ir/paper/280047/en

    Vancouver: Copy

    MONTAZERI GH.. CURRENT TREATMENT OF CHRONIC HEPATITIS B . ARCHIVES OF IRANIAN MEDICINE[Internet]. 2006;9(1):1-10. Available from: https://sid.ir/paper/280047/en

    IEEE: Copy

    GH. MONTAZERI, “CURRENT TREATMENT OF CHRONIC HEPATITIS B ,” ARCHIVES OF IRANIAN MEDICINE, vol. 9, no. 1, pp. 1–10, 2006, [Online]. Available: https://sid.ir/paper/280047/en

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