EPIDEMIOLOGY OF HEPATITIS B, HEPATITIS C, AND HUMAN IMMUNODEFICIENCY VIRUS INFECIONS IN PATIENTS WITH
BETA-THALASSEMIA IN IRAN: A MULTICENTER STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRMOUMEN SH.; ALAVIAN S.M.; HAJARIZADEH B.; KAFAEI J.; YEKTAPARAST B.; ZAHEDI M.J.; ZAND V.; AZAMI A.A.; HOSSEINI M.M.A.; FARIDI A.R.; HAJIBEYGI B.; DAVARI K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2006 | Volume:9 | Issue:4 Page(s): 319-323

Download Full-Text

View:

820

Download:

467

Cites:

Information Journal Paper

Title

EPIDEMIOLOGY OF HEPATITIS B, HEPATITIS C, AND HUMAN IMMUNODEFICIENCY VIRUS INFECIONS IN PATIENTS WITH BETA-THALASSEMIA IN IRAN: A MULTICENTER STUDY

Author(s)

Keywords

BLOOD TRANSFUSION

HUMAN IMMUNODEFICIENCY VIRUS

HEPATITIS B

HEPATITIS C

THALASSEMIA

Abstract

Background: Though regular BLOOD TRANSFUSION improves the overall survival of patients with β-thalassemia, it carries a definite risk of infection with blood-borne viruses. We carried out this multicenter study to provide epidemiologic data on HEPATITIS B virus (HBV), HEPATITIS C virus (HCV), and HUMAN IMMUNODEFICIENCY VIRUS (HIV) infection among Iranian β-thalassemic patients. Moreover, HCV infection-associated risk factors were investigated in this population. Methods: Seven hundred and thirty-two patients with β-thalassemia major or β-thalassemia intermedia, selected from five provinces of Iran including Tehran (n = 410), Kerman (n = 100), Qazvin (n = 95), Semnan (n = 81), and Zanjan (n = 46), were enrolled in this study. Using ELISA, their sera were tested for HBsAg, HBcAb, HBsAb, HCVAb, and HIVAb. The positive HCVAb results were confirmed by RIBA-2nd generation. Results: The study sample consisted of 413 males and 319 females, with a mean ± SD age of 17.9 ± 9.0 years. One hundred forty-one (19.3%) patients were HCVAb positive; 11 (1.5%) were HBsAg positive. No one was HIVAb positive. Univariate analysis showed that β-thalassemia major (P = 0.01), older age (P = 0.001), longer transfusion duration (P = 0.000), HBsAg seropositivity (P = 0.03), and higher serum ferritin level (P = 0.002) were significantly associated with a higher prevalence of HCV. Furthermore, the prevalence of HCV infection dropped significantly after the implementation of blood donors screening (22.8% vs. 2.6%; P = 0.000). Using multivariate analysis, β-thalassemia major (P = 0.002), age (P < 0.001), serum ferritin level (P < 0.001), as well as consumption of unscreened blood (P = 0.003), were independent factors associated with HCV infection. Conclusion: The prevalence of HCV infection is much higher among Iranian β-thalassemic patients as compared with HBV and HIV infections. Routine screening of donated blood for HCV is highly recommended.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRMOUMEN, SH., ALAVIAN, S.M., HAJARIZADEH, B., KAFAEI, J., YEKTAPARAST, B., ZAHEDI, M.J., ZAND, V., AZAMI, A.A., HOSSEINI, M.M.A., FARIDI, A.R., HAJIBEYGI, B., & DAVARI, K.. (2006). EPIDEMIOLOGY OF HEPATITIS B, HEPATITIS C, AND HUMAN IMMUNODEFICIENCY VIRUS INFECIONS IN PATIENTS WITH BETA-THALASSEMIA IN IRAN: A MULTICENTER STUDY. ARCHIVES OF IRANIAN MEDICINE, 9(4), 319-323. SID. https://sid.ir/paper/280136/en

Vancouver: Copy

MIRMOUMEN SH., ALAVIAN S.M., HAJARIZADEH B., KAFAEI J., YEKTAPARAST B., ZAHEDI M.J., ZAND V., AZAMI A.A., HOSSEINI M.M.A., FARIDI A.R., HAJIBEYGI B., DAVARI K.. EPIDEMIOLOGY OF HEPATITIS B, HEPATITIS C, AND HUMAN IMMUNODEFICIENCY VIRUS INFECIONS IN PATIENTS WITH BETA-THALASSEMIA IN IRAN: A MULTICENTER STUDY. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2006;9(4):319-323. Available from: https://sid.ir/paper/280136/en

IEEE: Copy

SH. MIRMOUMEN, S.M. ALAVIAN, B. HAJARIZADEH, J. KAFAEI, B. YEKTAPARAST, M.J. ZAHEDI, V. ZAND, A.A. AZAMI, M.M.A. HOSSEINI, A.R. FARIDI, B. HAJIBEYGI, and K. DAVARI, “EPIDEMIOLOGY OF HEPATITIS B, HEPATITIS C, AND HUMAN IMMUNODEFICIENCY VIRUS INFECIONS IN PATIENTS WITH BETA-THALASSEMIA IN IRAN: A MULTICENTER STUDY,” ARCHIVES OF IRANIAN MEDICINE, vol. 9, no. 4, pp. 319–323, 2006, [Online]. Available: https://sid.ir/paper/280136/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops