DURATION OF SPINAL ANESTHESIA WITH BUPIVACAINE IN CHRONIC OPIUM ABUSERS UNDERGOING LOWER EXTREMITY ORTHOPEDIC SURGERY

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DABAGH ALI; DAHI TALEGHANI M.; ELYASI H.A.; VOSOUGHIAN M.; MALEK B.; RAJAEI S.; MAFTUH H.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2007 | Volume:10 | Issue:3 Page(s): 316-320

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Title

DURATION OF SPINAL ANESTHESIA WITH BUPIVACAINE IN CHRONIC OPIUM ABUSERS UNDERGOING LOWER EXTREMITY ORTHOPEDIC SURGERY

Author(s)

Keywords

BUPIVACAINE

CROSS-TOLERANCE

OPIUM ABUSE

PAIN RECEPTOR

SPINAL ANESTHESIA

Abstract

Background: It has been demonstrated that chronic OPIUM ABUSErs have lower thresholds for pain. SPINAL ANESTHESIA is a common procedure in anesthesia, which is performed through administration of drugs (usually local anesthetics) in the intrathecal space, to produce temporary pain relief. The aim of this study was to determine whether chronic OPIUM ABUSE could have any possible effect on the duration of spinal block by BUPIVACAINE. Methods: In a case-control study, 50 OPIUM ABUSErs and 50 nonabusers undergoing lower extremity orthopedic operations were selected from the patients admitted in Taleghani Hospital in Tehran for elective surgery. The study parameters were assimilated as much as possible, including the method of anesthesia. Results: No statistically significant difference was noted between the two groups regarding the age, sex, and duration of surgery; while, the duration of sensory block was much shorter in the OPIUM ABUSErs (86.6 ± 15.7 minutes) compared with the nonabusers (162 ± 22.1 minutes) (P < 0.0001). Conclusion: The study suggests a shortened duration of spinal block with BUPIVACAINE in OPIUM ABUSErs. The results can propose a number of possible mechanisms including crosstolerance mechanisms between local anesthetics and opioid compounds at the level of spinal neurons. Further molecular studies at the level of spine are suggested.

Cites

INVESTIGATING THE EFFECTS OF ADDING FENTANYL TO BUPIVACAINE IN SPINAL ANESTHESIA OF OPIUM-ADDICTED PATIENTS

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APA: Copy

DABAGH, ALI, DAHI TALEGHANI, M., ELYASI, H.A., VOSOUGHIAN, M., MALEK, B., RAJAEI, S., & MAFTUH, H.. (2007). DURATION OF SPINAL ANESTHESIA WITH BUPIVACAINE IN CHRONIC OPIUM ABUSERS UNDERGOING LOWER EXTREMITY ORTHOPEDIC SURGERY. ARCHIVES OF IRANIAN MEDICINE, 10(3), 316-320. SID. https://sid.ir/paper/280218/en

Vancouver: Copy

DABAGH ALI, DAHI TALEGHANI M., ELYASI H.A., VOSOUGHIAN M., MALEK B., RAJAEI S., MAFTUH H.. DURATION OF SPINAL ANESTHESIA WITH BUPIVACAINE IN CHRONIC OPIUM ABUSERS UNDERGOING LOWER EXTREMITY ORTHOPEDIC SURGERY. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2007;10(3):316-320. Available from: https://sid.ir/paper/280218/en

IEEE: Copy

ALI DABAGH, M. DAHI TALEGHANI, H.A. ELYASI, M. VOSOUGHIAN, B. MALEK, S. RAJAEI, and H. MAFTUH, “DURATION OF SPINAL ANESTHESIA WITH BUPIVACAINE IN CHRONIC OPIUM ABUSERS UNDERGOING LOWER EXTREMITY ORTHOPEDIC SURGERY,” ARCHIVES OF IRANIAN MEDICINE, vol. 10, no. 3, pp. 316–320, 2007, [Online]. Available: https://sid.ir/paper/280218/en

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