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Information Journal Paper

Title

EFFECT OF LITHIUM ON SWIM STRESS-INDUCED ANTINOCICEPTION IN NAIVE MICE AND MICE WITH SUBCHRONIC ADMINISTRATION OF MORPHINE OR SWIM STRESS IN FORMALIN TEST

Pages

  166-172

Abstract

 Background: Lithium has been shown to relieve mania and induce antinociception. In the present study, swim stress at 8°C induced antinociception in both phases of the FORMALIN TEST. Intraperitoneal administration of lithium chloride (LiCl) (0.05, 0.25, and 0.5 mg/kg) also induced antinociception in both phases of the FORMALIN TEST. Methods: Antinociception was assessed by the FORMALIN TEST method. Swim stress was achieved in the 8°C water in a container 5 cm in diameter and 20 cm tall filled with water do a depth of 11 cm. Results: The drug (0.5 and 5 mg/kg) potentiated SWIM STRESS-INDUCED ANTINOCICEPTION in the second phase of the test. Repeated exposure to water swimming stress with a period of 40 sec, once daily for three days, in combination with lithium chloride did not alter stress-induced antinociception in either phases of the FORMALIN TEST, when SWIM STRESS-INDUCED ANTINOCICEPTION was tested on the fourth day. Subchronic treatment with morphine (25 mg/kg), once daily for three days, in the presence or absence of lithium chloride (5 mg/kg) did not alter SWIM STRESS-INDUCED ANTINOCICEPTION, either, when SWIM STRESS-INDUCED ANTINOCICEPTION was tested on the fourth day. Conclusion: It may be concluded that lithium chloride potentiates SWIM STRESS-INDUCED ANTINOCICEPTION, but the drug has no influence on the response of subchronic administration swim stress or morphine.

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    • Cite

    APA: Copy

    FAZLI TABAEI, S., BAZAZ, N., MODIRZADEH, A., MAGHSOUDI, A., & ZARINDAST, M.R.. (2008). EFFECT OF LITHIUM ON SWIM STRESS-INDUCED ANTINOCICEPTION IN NAIVE MICE AND MICE WITH SUBCHRONIC ADMINISTRATION OF MORPHINE OR SWIM STRESS IN FORMALIN TEST. ARCHIVES OF IRANIAN MEDICINE, 11(2), 166-172. SID. https://sid.ir/paper/280295/en

    Vancouver: Copy

    FAZLI TABAEI S., BAZAZ N., MODIRZADEH A., MAGHSOUDI A., ZARINDAST M.R.. EFFECT OF LITHIUM ON SWIM STRESS-INDUCED ANTINOCICEPTION IN NAIVE MICE AND MICE WITH SUBCHRONIC ADMINISTRATION OF MORPHINE OR SWIM STRESS IN FORMALIN TEST. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(2):166-172. Available from: https://sid.ir/paper/280295/en

    IEEE: Copy

    S. FAZLI TABAEI, N. BAZAZ, A. MODIRZADEH, A. MAGHSOUDI, and M.R. ZARINDAST, “EFFECT OF LITHIUM ON SWIM STRESS-INDUCED ANTINOCICEPTION IN NAIVE MICE AND MICE WITH SUBCHRONIC ADMINISTRATION OF MORPHINE OR SWIM STRESS IN FORMALIN TEST,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 2, pp. 166–172, 2008, [Online]. Available: https://sid.ir/paper/280295/en

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