EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST

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FAZLI TABAEI S.; MAGHSOUDI A.; BAZAZ A.; BAZAZ N.; MODIRZADEH A.; ZARINDAST M.R.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2008 | Volume:11 | Issue:3 Page(s): 286-292

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Title

EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST

Author(s)

Keywords

DEXTROMETHORPHAN

FORMALIN TEST

MICE

SWIM-STRESS-INDUCED ANTINOCICEPTION

TOLERANCE

Abstract

Background: In the present study, the effect of DEXTROMETHORPHAN on antinociception and TOLERANCE induced by water swim-stress in the FORMALIN TEST was investigated.Methods: Swim- stress at 80C induces antinociception in both phases of the FORMALIN TEST.Intraperitoneal administration of DEXTROMETHORPHAN (60 mg/kg) also induces antinociception in the second phase of the FORMALIN TEST. The lower doses of DEXTROMETHORPHAN (1.25, 2.5, and 5 mg/kg) which did not induce antinociception alone, but did so in combination with swim- stress (40 second), showed antinociceptive effect in both phases of the test. Exposure to water swimming stress with a period of 20 sec, once daily for three days, altered swim- stress- induced antinociception in the FORMALIN TEST, when tested on the fourth day.Results: In these animals, exposure to either water swimming stress alone or water swimming stress in combination with DEXTROMETHORPHAN showed potentiation of antinociception induced by swim- stress up to 20 second and decreased the response induced by 40 and 60 second swimstress, indicating a TOLERANCE induction. DEXTROMETHORPHAN (20 mg/kg) did not alter the changes induced by three days exposure to swim- stress.Conclusion: The results may indicate a possible involvement of n-methyl-d-aspartate receptor mechanism in the antinociception but not TOLERANCE induced by swim- stress at 8°C.

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APA: Copy

FAZLI TABAEI, S., MAGHSOUDI, A., BAZAZ, A., BAZAZ, N., MODIRZADEH, A., & ZARINDAST, M.R.. (2008). EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST. ARCHIVES OF IRANIAN MEDICINE, 11(3), 286-292. SID. https://sid.ir/paper/280330/en

Vancouver: Copy

FAZLI TABAEI S., MAGHSOUDI A., BAZAZ A., BAZAZ N., MODIRZADEH A., ZARINDAST M.R.. EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(3):286-292. Available from: https://sid.ir/paper/280330/en

IEEE: Copy

S. FAZLI TABAEI, A. MAGHSOUDI, A. BAZAZ, N. BAZAZ, A. MODIRZADEH, and M.R. ZARINDAST, “EFFECT OF DEXTROMETHORPHAN ON ANTINOCICEPTION AND TOLERANCE INDUCED BY SWIM-STRESS IN THE FORMALIN TEST,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 3, pp. 286–292, 2008, [Online]. Available: https://sid.ir/paper/280330/en

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