مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF CYS 311 SER POLYMORPHISM OF PARAOXONASE-2 GENE WITH THE RISK OF CORONARY ARTERY DISEASE

Pages

  544-549

Abstract

 Background: Recently another member of the paraoxonase gene family designated PARAOXONASE-2 has been identified. PARAOXONASE-2 has antioxidant properties similar to paraoxonase-1 and paraoxonase-3. However, in contrast to paraoxonase-1 and paraoxonase-3, PARAOXONASE-2 is not associated with high-density lipoprotein and may only exert its antioxidant function at the cellular level.Methods: We assessed the frequency and genotype distribution of cys 311 ser PARAOXONASE-2 POLYMORPHISM in 300 subjects (>40 years old) with angiographic documentation of CORONARY ARTERY DISEASE (150 patients with >50% stenosis served as cases and 150 individuals with <20% stenosis served as controls) to determine the possible association between this mutation and susceptibility for CORONARY ARTERY DISEASE. The PARAOXONASE-2 genotypes were determined by polymerase chain reaction and DdeI restriction enzyme digestion.Results: The cases (CORONARY ARTERY DISEASE positive patients) showed significant differences in the distribution of cys 311 ser PARAOXONASE-2 genotypes as compared with the controls (CORONARY ARTERY DISEASE negative subjects, P=0.015). The analysis of PARAOXONASE-2 genotypes distribution showed higher percentage of CC genotype among CORONARY ARTERY DISEASE positive compared with CORONARY ARTERY DISEASE negative (P=0.008). After controlling for other risk factors, the cys 311 ser POLYMORPHISM had not correlation with age, body mass index, gender, smoking, diabetes, level of high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol.Conclusion: Our data indicate a major effect of the PARAOXONASE-2 POLYMORPHISM on CORONARY ARTERY DISEASE risk in patients referred to Shariati Hospital in Tehran.

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    • Cite

    APA: Copy

    JALALIAN, ALI, JAVADI, EBRAHIM, AKRAMI, M., FAKHRZADEH, H., HESHMAT, RAMIN, RAHMANI, MAZAHER, & BANDARIAN, F.. (2008). ASSOCIATION OF CYS 311 SER POLYMORPHISM OF PARAOXONASE-2 GENE WITH THE RISK OF CORONARY ARTERY DISEASE. ARCHIVES OF IRANIAN MEDICINE, 11(5), 544-549. SID. https://sid.ir/paper/280335/en

    Vancouver: Copy

    JALALIAN ALI, JAVADI EBRAHIM, AKRAMI M., FAKHRZADEH H., HESHMAT RAMIN, RAHMANI MAZAHER, BANDARIAN F.. ASSOCIATION OF CYS 311 SER POLYMORPHISM OF PARAOXONASE-2 GENE WITH THE RISK OF CORONARY ARTERY DISEASE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(5):544-549. Available from: https://sid.ir/paper/280335/en

    IEEE: Copy

    ALI JALALIAN, EBRAHIM JAVADI, M. AKRAMI, H. FAKHRZADEH, RAMIN HESHMAT, MAZAHER RAHMANI, and F. BANDARIAN, “ASSOCIATION OF CYS 311 SER POLYMORPHISM OF PARAOXONASE-2 GENE WITH THE RISK OF CORONARY ARTERY DISEASE,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 5, pp. 544–549, 2008, [Online]. Available: https://sid.ir/paper/280335/en

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