HIGH EXPRESSION OF MINICHROMOSOME MAINTENANCE PROTEIN 6 IN CLASSIC HODGKIN'S LYMPHOMA POINTS TO A CELL CYCLE ARREST IN G1 PHASE

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KARIMI SHIRIN; MOHAMMADI FOROUZAN; KHODADAD K.; EMAMI HABIB; SEYF ELAHI L.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2008 | Volume:11 | Issue:5 Page(s): 532-538

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Title

HIGH EXPRESSION OF MINICHROMOSOME MAINTENANCE PROTEIN 6 IN CLASSIC HODGKIN'S LYMPHOMA POINTS TO A CELL CYCLE ARREST IN G1 PHASE

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Keywords

CELL CYCLE

CELL PROLIFERATION

HODGKIN’S LYMPHOMA

KI-67

MCM6

Abstract

Background: Minichromosome maintenance protein 6 (MCM6) is one of the six proteins of minichromosome maintenance family that are involved in the initiation of DNA replication and thus represent a marker for proliferating cells. The aim of this study was to determine the proliferation characteristics of neoplastic cells in patients with classic Hodgkin's lymphoma.Methods: Paraffin-embedded blocks of lymph node, mediastinal, subcutaneous chest wall, and lung mass biopsies of 55 patients with classic Hodgkin's lymphoma were immunostained by the proliferation-associated monoclonal antibodies; Ki-S5 (Ki-67 antigen) and Ki-MCM6 (MCM6 antigen).Results: High MCM6 antigen expression was a striking feature of Hodgkin's and Reed- Sternberg cells (median: 85%, range: 35 – 99%) in comparison with lower KI-67 expression (median: 63.5%, range: 1 – 98%, P<0.001). This indicates that MCM6 is already expressed in the early G1 phase, a CELL CYCLE fraction that is not covered by antibodies specific to the KI-67 antigen. The proliferation rates were determined by two markers, independent of histologic subtype, stage, presence of B symptoms, and size.Conclusion: These data show that a subset of Reed-Sternberg and Hodgkin’s cells is arrested in the early G1 phase and the MCM6-positive cells do not necessarily represent the real proliferating compartment of Hodgkin's lymphoma. Clinical relevance of this marker in patients with Hodgkin's lymphoma should be investigated.

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APA: Copy

KARIMI, SHIRIN, MOHAMMADI, FOROUZAN, KHODADAD, K., EMAMI, HABIB, & SEYF ELAHI, L.. (2008). HIGH EXPRESSION OF MINICHROMOSOME MAINTENANCE PROTEIN 6 IN CLASSIC HODGKIN'S LYMPHOMA POINTS TO A CELL CYCLE ARREST IN G1 PHASE. ARCHIVES OF IRANIAN MEDICINE, 11(5), 532-538. SID. https://sid.ir/paper/280351/en

Vancouver: Copy

KARIMI SHIRIN, MOHAMMADI FOROUZAN, KHODADAD K., EMAMI HABIB, SEYF ELAHI L.. HIGH EXPRESSION OF MINICHROMOSOME MAINTENANCE PROTEIN 6 IN CLASSIC HODGKIN'S LYMPHOMA POINTS TO A CELL CYCLE ARREST IN G1 PHASE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(5):532-538. Available from: https://sid.ir/paper/280351/en

IEEE: Copy

SHIRIN KARIMI, FOROUZAN MOHAMMADI, K. KHODADAD, HABIB EMAMI, and L. SEYF ELAHI, “HIGH EXPRESSION OF MINICHROMOSOME MAINTENANCE PROTEIN 6 IN CLASSIC HODGKIN'S LYMPHOMA POINTS TO A CELL CYCLE ARREST IN G1 PHASE,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 5, pp. 532–538, 2008, [Online]. Available: https://sid.ir/paper/280351/en

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