POST-TRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION: REPORT OF 5 CASES AMONG MORE THAN 550 LIVER TRANSPLANTS IN IRAN

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GERAMIZADEH B.; MALEKHOSSEINI SEYED ALI; BAHADOR ALI; SALAHI H.A.; NIK EGHBALIAN S.; SHARIFIAN MARYAM; BAGHERI LANKARANI KAMRAN; IMANIEH M.H.; DEHGHANI MOHSEN

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2010 | Volume:13 | Issue:5 Page(s): 417-419

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Title

POST-TRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION: REPORT OF 5 CASES AMONG MORE THAN 550 LIVER TRANSPLANTS IN IRAN

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LIVER

POST-TRSNAPLANTATION LYMPHOPROLIFERATIVE DISORDER

Abstract

Background: Post-transplantation lymphoproliferative disorders (PTLD) are a spectrum of diseases defined as polyclonal or monoclonal proliferations of lymphocytes which occur after solid organ transplants. In this study, we report our first experiences with PTLD following LIVER transplantation in Iran.Patients and Methods: We retrospectively analyzed five cases of PTLD which followed LIVER transplantation among more than 550 LIVER transplants in our center. Of these, three were pediatric cases and two were adults. The underlying causes were tyrosinemia, autoimmune hepatitis, and progressive familial intrahepatic cholestasis (PFIC) in the three pediatric cases. HCV hepatitis was the primary cause for cirrhosis in one of the adults and the other adult was labeled as cryptogenic cirrhosis. All cases, except for one, developed PTLD during the first year following LIVER transplantation. Results: Patients were diagnosed as PTLD, B-cell, MALT and Hodgkin-like (according to the WHO classification of PTLD). The three pediatric patients died despite discontinuation of immunosuppressive drugs and chemotherapy. Fortunately both adult patients, until now, are still alive.Conclusion: The incidence of PTLD in our center is lower than previous reports from other centers (0.9%), with a 60% mortality rate and worse prognosis in the pediatric age group.

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APA: Copy

GERAMIZADEH, B., MALEKHOSSEINI, SEYED ALI, BAHADOR, ALI, SALAHI, H.A., NIK EGHBALIAN, S., SHARIFIAN, MARYAM, BAGHERI LANKARANI, KAMRAN, IMANIEH, M.H., & DEHGHANI, MOHSEN. (2010). POST-TRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION: REPORT OF 5 CASES AMONG MORE THAN 550 LIVER TRANSPLANTS IN IRAN. ARCHIVES OF IRANIAN MEDICINE, 13(5), 417-419. SID. https://sid.ir/paper/280605/en

Vancouver: Copy

GERAMIZADEH B., MALEKHOSSEINI SEYED ALI, BAHADOR ALI, SALAHI H.A., NIK EGHBALIAN S., SHARIFIAN MARYAM, BAGHERI LANKARANI KAMRAN, IMANIEH M.H., DEHGHANI MOHSEN. POST-TRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION: REPORT OF 5 CASES AMONG MORE THAN 550 LIVER TRANSPLANTS IN IRAN. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2010;13(5):417-419. Available from: https://sid.ir/paper/280605/en

IEEE: Copy

B. GERAMIZADEH, SEYED ALI MALEKHOSSEINI, ALI BAHADOR, H.A. SALAHI, S. NIK EGHBALIAN, MARYAM SHARIFIAN, KAMRAN BAGHERI LANKARANI, M.H. IMANIEH, and MOHSEN DEHGHANI, “POST-TRANSPLANTATION LYMPHOPROLIFERATIVE DISORDER AFTER LIVER TRANSPLANTATION: REPORT OF 5 CASES AMONG MORE THAN 550 LIVER TRANSPLANTS IN IRAN,” ARCHIVES OF IRANIAN MEDICINE, vol. 13, no. 5, pp. 417–419, 2010, [Online]. Available: https://sid.ir/paper/280605/en

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