PLASMA MYELOPEROXIDASE ACTIVITY AND APOLIPOPROTEIN A-1 EXPRESSION IN CHRONIC HEPATITIS B PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMADKHANI ASHRAF; RASTGAR JAZII FERDOUS; SAYEHMIRI KOUROSH; JAFARI NEJAD SAEIDEH; MONTASER KOUHSARI LALEH; POUSTCHI HOSSEIN; MONTAZERI GHODRATOLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2011 | Volume:14 | Issue:4 Page(s): 254-258

Download Full-Text

View:

300

Download:

Cites:

Information Journal Paper

Title

PLASMA MYELOPEROXIDASE ACTIVITY AND APOLIPOPROTEIN A-1 EXPRESSION IN CHRONIC HEPATITIS B PATIENTS

Author(s)

Keywords

APOLIPOPROTEIN A-1

CHRONIC HEPATITIS B

MYELOPEROXIDASE

TWO-DIMENSIONAL GEL ELECTROPHORESIS

Abstract

Background: Hepatitis B virus initiates a complicated cascade process leading to CHRONIC HEPATITIS B, cirrhosis, and hepatocellular carcinoma. In inflammatory situations, MYELOPEROXIDASE is released in plasma and binds to APOLIPOPROTEIN A-1 in high-density lipoproteins. This study aims to evaluate the level of plasma MYELOPEROXIDASE as well as the pattern of plasma proteins in patients with CHRONIC HEPATITIS B.Methods: Included in this study were 30 male subjects: 19 CHRONIC HEPATITIS B patients, 6 HBV-related cirrhotic patients, and 5 healthy controls. Plasma MYELOPEROXIDASE was measured using enzyme-linked immunosorbent assay. Proteomic analysis of plasma proteins was performed by TWO-DIMENSIONAL GEL ELECTROPHORESIS (2-DE) and mass spectrometry. One way ANOVA was used for data analysis.Results: Mean plasma MYELOPEROXIDASE levels were higher in patients with liver cirrhosis (65.5±12.5; P=0.007) and CHRONIC HEPATITIS B (53.7±10.6; P=0.18) when compared with healthy subjects (45±7.6). Moreover, a positive correlation was found between plasma MYELOPEROXIDASE levels and hepatic fibrosis stage (r=0.53, P=0.002; r=0.63, P=0.000). Proteomic analysis showed an altered plasma protein pattern in progressive hepatitis B and down-regulation of the major APOLIPOPROTEIN A-1 along with the appearance of a variety of spots noted to be APOLIPOPROTEIN A-1isoforms with different molecular masses.Conclusion: In this study, progressive liver injury due to HBV infection correlated with higher plasma MYELOPEROXIDASE and an altered plasma APOLIPOPROTEIN A-1pattern.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAMADKHANI, ASHRAF, RASTGAR JAZII, FERDOUS, SAYEHMIRI, KOUROSH, JAFARI NEJAD, SAEIDEH, MONTASER KOUHSARI, LALEH, POUSTCHI, HOSSEIN, & MONTAZERI, GHODRATOLAH. (2011). PLASMA MYELOPEROXIDASE ACTIVITY AND APOLIPOPROTEIN A-1 EXPRESSION IN CHRONIC HEPATITIS B PATIENTS. ARCHIVES OF IRANIAN MEDICINE, 14(4), 254-258. SID. https://sid.ir/paper/280665/en

Vancouver: Copy

MOHAMADKHANI ASHRAF, RASTGAR JAZII FERDOUS, SAYEHMIRI KOUROSH, JAFARI NEJAD SAEIDEH, MONTASER KOUHSARI LALEH, POUSTCHI HOSSEIN, MONTAZERI GHODRATOLAH. PLASMA MYELOPEROXIDASE ACTIVITY AND APOLIPOPROTEIN A-1 EXPRESSION IN CHRONIC HEPATITIS B PATIENTS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(4):254-258. Available from: https://sid.ir/paper/280665/en

IEEE: Copy

ASHRAF MOHAMADKHANI, FERDOUS RASTGAR JAZII, KOUROSH SAYEHMIRI, SAEIDEH JAFARI NEJAD, LALEH MONTASER KOUHSARI, HOSSEIN POUSTCHI, and GHODRATOLAH MONTAZERI, “PLASMA MYELOPEROXIDASE ACTIVITY AND APOLIPOPROTEIN A-1 EXPRESSION IN CHRONIC HEPATITIS B PATIENTS,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 4, pp. 254–258, 2011, [Online]. Available: https://sid.ir/paper/280665/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops