CO-INHERITANCE OF HEMOGLOBIN D AND -THALASSEMIA TRAITS IN THREE IRANIAN FAMILIES: CLINICAL RELEVANCE

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TAGHAVI BASMANJ MARYAM; KARIMIPOOR MORTEZA; AMIRIAN AZAM; JAFARINEJAD MASOUMEH; KATOUZIAN LEILA; VALAEI ATEFEH; BAYAT FATEMEH; KORDAFSHARI ALIREZA; ZEINALI SIROUS

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2011 | Volume:14 | Issue:1 Page(s): 61-63

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Title

CO-INHERITANCE OF HEMOGLOBIN D AND -THALASSEMIA TRAITS IN THREE IRANIAN FAMILIES: CLINICAL RELEVANCE

Author(s)

Keywords

ARMS-PCR

β-THALASSEMIA

HBD

HETEROZYGOUS

IRAN

Abstract

Here we report the result of three cases referred to our lab that had a combination of b-thalassemia and hemoglobin D (Hb D) traits. These individuals had no symptoms of profound anemia and hematological indices were similar to that of a b-thalassemia heterozygote. In all three cases, the Hb D level was elevated and no HbA was detected electrophoretically.The electrophoresis pattern suggested that all cases were homozygotes for Hb D. PCR followed by digestion with EcoRI and sequencing of the b-globin gene confirmed the presence of Cd 121 GAA>CAA in the HETEROZYGOUS form with another b-globin mutation. In all cases, the mutations in the b-globin gene were detected by ARMS PCR technique and they were either IVSII-I or IVSI-5. Hematological studies of the family members showed that thalassemia which caused the mutations and Hb D were in thetrans position.

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APA: Copy

TAGHAVI BASMANJ, MARYAM, KARIMIPOOR, MORTEZA, AMIRIAN, AZAM, JAFARINEJAD, MASOUMEH, KATOUZIAN, LEILA, VALAEI, ATEFEH, BAYAT, FATEMEH, KORDAFSHARI, ALIREZA, & ZEINALI, SIROUS. (2011). CO-INHERITANCE OF HEMOGLOBIN D AND -THALASSEMIA TRAITS IN THREE IRANIAN FAMILIES: CLINICAL RELEVANCE. ARCHIVES OF IRANIAN MEDICINE, 14(1), 61-63. SID. https://sid.ir/paper/280726/en

Vancouver: Copy

TAGHAVI BASMANJ MARYAM, KARIMIPOOR MORTEZA, AMIRIAN AZAM, JAFARINEJAD MASOUMEH, KATOUZIAN LEILA, VALAEI ATEFEH, BAYAT FATEMEH, KORDAFSHARI ALIREZA, ZEINALI SIROUS. CO-INHERITANCE OF HEMOGLOBIN D AND -THALASSEMIA TRAITS IN THREE IRANIAN FAMILIES: CLINICAL RELEVANCE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(1):61-63. Available from: https://sid.ir/paper/280726/en

IEEE: Copy

MARYAM TAGHAVI BASMANJ, MORTEZA KARIMIPOOR, AZAM AMIRIAN, MASOUMEH JAFARINEJAD, LEILA KATOUZIAN, ATEFEH VALAEI, FATEMEH BAYAT, ALIREZA KORDAFSHARI, and SIROUS ZEINALI, “CO-INHERITANCE OF HEMOGLOBIN D AND -THALASSEMIA TRAITS IN THREE IRANIAN FAMILIES: CLINICAL RELEVANCE,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 1, pp. 61–63, 2011, [Online]. Available: https://sid.ir/paper/280726/en

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