MOLECULAR CYTOGENETIC ANALYSIS OF CHEMORESISTANT NON-HODGKIN’S LYMPHOMA PATIENTS WITH P53 ABNORMALITIES USING FLUORESCENCE IN SITU HYBRIDISATION AND COMPARATIVE GENOMIC HYBRIDISATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FOROUTAN BEHZAD; ZITZELSBERGER HORST; BAUER VERENA; RUF AFRUJ ALI; BAUMGARTNER ADOLF; ANDERSON DIANA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2011 | Volume:14 | Issue:5 Page(s): 321-326

Download Full-Text

View:

307

Download:

214

Cites:

Information Journal Paper

Title

MOLECULAR CYTOGENETIC ANALYSIS OF CHEMORESISTANT NON-HODGKIN’S LYMPHOMA PATIENTS WITH P53 ABNORMALITIES USING FLUORESCENCE IN SITU HYBRIDISATION AND COMPARATIVE GENOMIC HYBRIDISATION

Author(s)

Keywords

CELLULAR BIOMARKER

CHEMORESISTANCE

P-GP

P53

Abstract

Background: Alterations of the P53 gene at 17p13.1 as well as the gene for a transmembrane p-glycoprotein, ABCB1 (MDR-1) at 7q21.12, have been shown to be mostly associated with the phenomenon of multi-drug resistance (MDR) in human cancers. In order to better understand the mechanisms by which CHEMORESISTANCE is mediated, non-hodgkin’s lymphoma (NHL) patients overexpressing P53 mutant protein and resistant to CHOP chemotherapy, NHL patients without P53 overexpression and a Burkitt’s lymphoma Raji cell line with P53 overexpression have been evaluated using uorescent in situ hybridization (FISH) and comparative genomic hybridization (CGH).Methods: Three chromosomes (1, 7, and 17) known to be associated with MDR and the presence of P53 mutant protein, were analysed by FISH.Results: No obvious chromosomal aberrations such as translocations were found in any of the patients when compared to healthy individuals, which suggests that the three selected chromosomes might not be specifically related to NHL, with or without P53 overexpression. For CGH, gains and losses of chromosomal material have been identified and the changes were not only limited to the three selected chromosomes associated with MDR. A detailed analysis of the recurrent aberrations shows that most of the NHL patients have alterations on the chromosome arms 1p, 6q, 7q, 20q, 22q, and Xp, whereas patients with P53 overexpression predominantly show aberrations on 4p and 17q.Conclusion: Further characterisation of the genetic regions identified might more closely contribute to our understanding of acquired MDR in NHL. Alterations in the three evaluated chromosomes may be prevalent in other tumours. In the present study, using FISH and CGH, there was insufficient difference between NHL patients with and without P53 overexpression.

Cites

No record.

References

No record.

Cite

APA: Copy

FOROUTAN, BEHZAD, ZITZELSBERGER, HORST, BAUER, VERENA, RUF, AFRUJ ALI, BAUMGARTNER, ADOLF, & ANDERSON, DIANA. (2011). MOLECULAR CYTOGENETIC ANALYSIS OF CHEMORESISTANT NON-HODGKIN’S LYMPHOMA PATIENTS WITH P53 ABNORMALITIES USING FLUORESCENCE IN SITU HYBRIDISATION AND COMPARATIVE GENOMIC HYBRIDISATION. ARCHIVES OF IRANIAN MEDICINE, 14(5), 321-326. SID. https://sid.ir/paper/280735/en

Vancouver: Copy

FOROUTAN BEHZAD, ZITZELSBERGER HORST, BAUER VERENA, RUF AFRUJ ALI, BAUMGARTNER ADOLF, ANDERSON DIANA. MOLECULAR CYTOGENETIC ANALYSIS OF CHEMORESISTANT NON-HODGKIN’S LYMPHOMA PATIENTS WITH P53 ABNORMALITIES USING FLUORESCENCE IN SITU HYBRIDISATION AND COMPARATIVE GENOMIC HYBRIDISATION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(5):321-326. Available from: https://sid.ir/paper/280735/en

IEEE: Copy

BEHZAD FOROUTAN, HORST ZITZELSBERGER, VERENA BAUER, AFRUJ ALI RUF, ADOLF BAUMGARTNER, and DIANA ANDERSON, “MOLECULAR CYTOGENETIC ANALYSIS OF CHEMORESISTANT NON-HODGKIN’S LYMPHOMA PATIENTS WITH P53 ABNORMALITIES USING FLUORESCENCE IN SITU HYBRIDISATION AND COMPARATIVE GENOMIC HYBRIDISATION,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 5, pp. 321–326, 2011, [Online]. Available: https://sid.ir/paper/280735/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops