COMPARISON OF THE EFFECT OF NON-ANTIFUNGAL AND ANTIFUNGA L AGENTS ON CANDIDA ISOLATES FROM THE GASTROINTESTINAL TRACT

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SIAVOSHI FARIDEH; TAVAKOLIAN ATEFEH; FOROUMADI ALIREZA; MOHAMMAD HOSSEINI NEGAR; MASSARRAT SADEGH; PEDRAMNIA SHAHRZAD; SANIEE PARASTOO

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2012 | Volume:15 | Issue:1 Page(s): 27-31

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Title

COMPARISON OF THE EFFECT OF NON-ANTIFUNGAL AND ANTIFUNGA L AGENTS ON CANDIDA ISOLATES FROM THE GASTROINTESTINAL TRACT

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Keywords

ANTIFUNGALS

CANDIDA SPP.

NON-ANTIFUNGALS

Abstract

Background: Non-antifungal drugs appear promising in treatment of opportunistic infections of CANDIDA SPP. that are often resistant to current ANTIFUNGALS.Methods: The broth macrodilution method (NCCLS M27-P document) was used to compare the antifungal activity of trifluoperazine, propranolol, and lansoprazole with that of ketoconazole and amphotericin B, using 50 yeast isolates from the GI tract. The minimum fungicidal concentrations (MFCs), resistance rates and the time required for fungicidal activity of the drugs (2-48 hours) were determined.Results: The most effective antifungal activity was exhibited by trifluoperazine. Its MFC was 32 mg/mL for Candida albicans (3.3% resistance) and CANDIDA SPP. (0% resistance) yeasts, and 64 mg/mL for Candida tropicalis with 10% resistance. The MFC for C. albicans and Candidaspp. was comparable to that of ketoconazole. However, the time required for the inhibitory effect (6 hr) was shorter than that of ketoconazole (48 hr) or amphotericin B (24 hr). The time required for the inhibitory activity onC. tropicalis was 24 hr, which was shorter than that of ketoconazole and amphotericin B (48 hr). A considerable number (40%) ofCandida spp. showed resistance to ketoconazole, and 20% of C. tropicalis showed resistance to amphotericin B. Trifluoperazine, an antipsychotic drug, exhibited effective antifungal activity with the MFC, comparable to ketoconazole (32mg/mL). Among the three yeast groups, C. tropical is showed resistance to trifluoperazine and amphotericin B, andCandida spp. was considerably resistant to ketoconazole.Conclusion: Trifluoperazine could be considered as an alternative antifungal when encountering CANDIDA SPP. resistant to current ANTIFUNGALS.

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APA: Copy

SIAVOSHI, FARIDEH, TAVAKOLIAN, ATEFEH, FOROUMADI, ALIREZA, MOHAMMAD HOSSEINI, NEGAR, MASSARRAT, SADEGH, PEDRAMNIA, SHAHRZAD, & SANIEE, PARASTOO. (2012). COMPARISON OF THE EFFECT OF NON-ANTIFUNGAL AND ANTIFUNGA L AGENTS ON CANDIDA ISOLATES FROM THE GASTROINTESTINAL TRACT. ARCHIVES OF IRANIAN MEDICINE, 15(1), 27-31. SID. https://sid.ir/paper/280783/en

Vancouver: Copy

SIAVOSHI FARIDEH, TAVAKOLIAN ATEFEH, FOROUMADI ALIREZA, MOHAMMAD HOSSEINI NEGAR, MASSARRAT SADEGH, PEDRAMNIA SHAHRZAD, SANIEE PARASTOO. COMPARISON OF THE EFFECT OF NON-ANTIFUNGAL AND ANTIFUNGA L AGENTS ON CANDIDA ISOLATES FROM THE GASTROINTESTINAL TRACT. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2012;15(1):27-31. Available from: https://sid.ir/paper/280783/en

IEEE: Copy

FARIDEH SIAVOSHI, ATEFEH TAVAKOLIAN, ALIREZA FOROUMADI, NEGAR MOHAMMAD HOSSEINI, SADEGH MASSARRAT, SHAHRZAD PEDRAMNIA, and PARASTOO SANIEE, “COMPARISON OF THE EFFECT OF NON-ANTIFUNGAL AND ANTIFUNGA L AGENTS ON CANDIDA ISOLATES FROM THE GASTROINTESTINAL TRACT,” ARCHIVES OF IRANIAN MEDICINE, vol. 15, no. 1, pp. 27–31, 2012, [Online]. Available: https://sid.ir/paper/280783/en

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