RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION

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ZARKESH MARYAM; HOSSEINPANAH FARHAD; BARZIN MARYAM; HOSSEINZADEH NIMA; GUITY KAMRAN; DANESHPOUR MARYAM SADAT; AZIZI FEREIDOUN

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2014 | Volume:17 | Issue:6 Page(s): 411-416

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Title

RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION

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Keywords

FAMILIAL AGGREGATION

METABOLIC SYNDROME

RECURRENCE RISK RATIO

TLGS

Abstract

BACKGROUND: In this study, we aimed to determine the extent of possible genetic influence on cardio-metabolic risk factors, evaluate the FAMILIAL AGGREGATION of MetS and estimate the siblings’ RECURRENCE RISK RATIOs in a Tehrani population.METHODS: In a cross-sectional observational study, we made anthropometric, blood pressure, and biochemical measurements in each member of 566 Tehrani nuclear families.RESULTS: Grandmothers had the highest incidence of atherosclerotic risk factors. Four factors were found which accounted for 77.7% of the overall variance. RECURRENCE RISK RATIO among siblings was 5.61 (95% conﬁdence interval [CI]: 3.15–9.97). The adjusted odds ratio (OR) of proband’s MetS status was 1.33 (95% CI: 1.06–1.67). The adjusted OR for the four factors to predict MetS were all signiﬁcant, with obesity having the highest risk (OR: 7.50, CI: 5.91–9.52), followed by dyslipidemia/hyperglycemia (OR: 4.86, CI: 4.03–5.87), and blood pressure (OR: 4.20, CI: 3.51–5.02).CONCLUSION: A high risk of MetS (five-fold) was found in siblings with MetS proband. Moreover, findings confirm the importance of obesity for the aggregation of MetS by nearly seven-fold in the study population.

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APA: Copy

ZARKESH, MARYAM, HOSSEINPANAH, FARHAD, BARZIN, MARYAM, HOSSEINZADEH, NIMA, GUITY, KAMRAN, DANESHPOUR, MARYAM SADAT, & AZIZI, FEREIDOUN. (2014). RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION. ARCHIVES OF IRANIAN MEDICINE, 17(6), 411-416. SID. https://sid.ir/paper/280968/en

Vancouver: Copy

ZARKESH MARYAM, HOSSEINPANAH FARHAD, BARZIN MARYAM, HOSSEINZADEH NIMA, GUITY KAMRAN, DANESHPOUR MARYAM SADAT, AZIZI FEREIDOUN. RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2014;17(6):411-416. Available from: https://sid.ir/paper/280968/en

IEEE: Copy

MARYAM ZARKESH, FARHAD HOSSEINPANAH, MARYAM BARZIN, NIMA HOSSEINZADEH, KAMRAN GUITY, MARYAM SADAT DANESHPOUR, and FEREIDOUN AZIZI, “RECURRENCE RISK RATIO OF SIBLINGS AND FAMILIAL AGGREGATION OF THE METABOLIC SYNDROME AMONG TEHRANIAN POPULATION,” ARCHIVES OF IRANIAN MEDICINE, vol. 17, no. 6, pp. 411–416, 2014, [Online]. Available: https://sid.ir/paper/280968/en

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