NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE

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VAND RAJABPOUR FATEMEH; RAOOFIAN REZA; HABIBI LALEH; AKRAMI SEYED MOHAMMAD; TABRIZI MINA

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2014 | Volume:17 | Issue:10 Page(s): 702-712

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Information Journal Paper

Title

NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE

Author(s)

Keywords

GENE THERAPY

GENETIC TRANSPOSITION

INDUCED PLURIPOTENT STEM CELL (IPSC)

TRANSPOSABLE ELEMENTS (TES)

TRANSPOSABLE ELEMENT BASED VECTORS (TEV)

Abstract

Forty-five percent of the human genome is composed of Transposable Elements (TEs); therefore, TEs have had an undisputed impact on evolution of the most evolved creature by a very simple mechanism of action. Scientists have been studying this simple mechanism of action and are currently using it to develop efficient and safe gene delivery systems especially for treatment of diseases. TEs have also been used safely in generating induced Pluripotent Stem Cells (iPSC) for regenerative medicine, which opens the door to a world of possibilities in our approach in trying to wrestle with many challenges in medicine. The PiggyBac (PB) system has yielded more success in generation of induced pluripotent stem cells in regenerative medicine, and the Sleeping Beauty (SB) has been more successful in GENE THERAPY. Recent advances are indicative of more good news to come regarding the potential heights of successes achievable by the use of the TE-based systems.

Cites

NOVEL THERAPEUTIC INTERVENTIONS IN HEREDITARY HEARING LOSS

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APA: Copy

VAND RAJABPOUR, FATEMEH, RAOOFIAN, REZA, HABIBI, LALEH, AKRAMI, SEYED MOHAMMAD, & TABRIZI, MINA. (2014). NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE. ARCHIVES OF IRANIAN MEDICINE, 17(10), 702-712. SID. https://sid.ir/paper/281129/en

Vancouver: Copy

VAND RAJABPOUR FATEMEH, RAOOFIAN REZA, HABIBI LALEH, AKRAMI SEYED MOHAMMAD, TABRIZI MINA. NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2014;17(10):702-712. Available from: https://sid.ir/paper/281129/en

IEEE: Copy

FATEMEH VAND RAJABPOUR, REZA RAOOFIAN, LALEH HABIBI, SEYED MOHAMMAD AKRAMI, and MINA TABRIZI, “NOVEL TRENDS IN GENETICS: TRANSPOSABLE ELEMENTS AND THEIR APPLICATION IN MEDICINE,” ARCHIVES OF IRANIAN MEDICINE, vol. 17, no. 10, pp. 702–712, 2014, [Online]. Available: https://sid.ir/paper/281129/en

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