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Information Journal Paper

Title

EXPRESSION AND CLINICAL SIGNIFICANCE OF CD82/KAI1 AND E-CADHERIN IN NON-SMALL CELL LUNG CANCER

Pages

  707-712

Keywords

E 

Abstract

 BACKGROUND: This study investigates the Expression of CD82/KAI1 and Epithelial-cadherin (E-cad) in non-small cell lung cancer (NSCLC).METHODS: Tissues of resected primary NSCLC and normal lung tissue were investigated. Protein Expression was detected with immunohistochemical staining. mRNA Expression levels of CD82/KAI1 and E-cad were determined by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) after mRNA Extraction.RESULTS: The Expression of CD82/KAI1 and E-cad was significantly lower in NSCLC compared to normal lung tissue (P<0.01). CD82/KAI1 and E-cad mRNA and protein Expression were found to be in close relationship with the grade of differentiation, lymph node metastasis and pathologic tumor-node-metastasis (pTNM) stages, and survival in NSCLC (P<0.01), but no relationship was observed with gender, diameter, type, histological type and age (P>0.05). Expression of mRNA CD82/KAI1 and E-cad were consistent with their proteins (P<0.01), and there was a significant relationship between Expression of CD82/KAI1 and E-cad. The survival rate of the CD82/KAI1-positive and CD82/KAI1-negative groups was significantly different (P<0.01). In addition, the survival rate was significantly different between the E-cad-positive and E-cad-negative groups. pTNM stages and positive Expression of CD82/KAI1 and E-cad were independent prognostic factors of NSCLC (P<0.05).CONCLUSION: Lower Expression of CD82/KAI1 and E-cad was found in NSCLC compared to normal lung tissue. Decreased Expression of CD82/KAI1 and E-cad was closely related to cellular differentiation, pTNM stages, invasion and metastasis.

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    • Cite

    APA: Copy

    SHIWU, WU, LAN, YU, WENQING, SONG, LEI, ZHOU, & YISHENG, TAO. (2012). EXPRESSION AND CLINICAL SIGNIFICANCE OF CD82/KAI1 AND E-CADHERIN IN NON-SMALL CELL LUNG CANCER. ARCHIVES OF IRANIAN MEDICINE, 15(11), 707-712. SID. https://sid.ir/paper/281217/en

    Vancouver: Copy

    SHIWU WU, LAN YU, WENQING SONG, LEI ZHOU, YISHENG TAO. EXPRESSION AND CLINICAL SIGNIFICANCE OF CD82/KAI1 AND E-CADHERIN IN NON-SMALL CELL LUNG CANCER. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2012;15(11):707-712. Available from: https://sid.ir/paper/281217/en

    IEEE: Copy

    WU SHIWU, YU LAN, SONG WENQING, ZHOU LEI, and TAO YISHENG, “EXPRESSION AND CLINICAL SIGNIFICANCE OF CD82/KAI1 AND E-CADHERIN IN NON-SMALL CELL LUNG CANCER,” ARCHIVES OF IRANIAN MEDICINE, vol. 15, no. 11, pp. 707–712, 2012, [Online]. Available: https://sid.ir/paper/281217/en

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